Assay for Parts-Per-Million Levels of Azide in Drug Substances
April 1st 2013The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of thi impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC.
How to Assess Potential Matrix Effects for LC-ESI-MS Trace Analysis
March 28th 2013Method validation is a concept that has been ingrained (or should have been ingrained) in the minds of most analytical chemists. Any new method that is created has to be proven reliable and provide some level of performance under well-defined conditions.
The LCGC Blog: Retention Time Variability in HPLC
March 26th 2013A number of retention time issues can cause problems in HPLC. Here's advice on how to handle common ones, such as retention time drift, temperature variability, problems arising from column equilibration, and difficulties validating a method.
Two triple quads achieve a new global standard in mass spectrometry
March 22nd 2013The two triple quadrupole mass spectrometers LCMS-8040 and GCMS-TQ8030 complete Shimadzu?s UFMS series consisting of seven powerful systems. The UFMS product family provides higher sensitivity, greater excellence in data quality, increased analytical throughput and a wider range of applications.