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Answers to common questions about operational qualification software.

In this month's instalment, we address common questions about various gases and their delivery to a gas chromatograph.

Application Note

This article discusses the details of how the newer techniques of sample prepaation are simplified by the use of LC–MS–MS and GC–MS–MS technology.

With so many HPLC columns on the market we present a simple guide to what's important when making your stationary phase and column dimension choices.

MS: The Practical Art Editor Kate Yu interviews Fred McLafferty about his pioneering career in mass spectrometry.

A panel of experts discuss the latest trends in sample preparaion.

Small solid rubber samples can be analyzed without sample preparation.

This article describes a new analytical method for the global profiling of molecular lipids in biological samples, with particular emphasis on the plasmalogen lipids.

Fast, easy, and resproducible determination of capsaicinoid content

A sensitive method that reduces the number of false-positive results

American Chemical Society Honors Brian Bidlingmeyer

A how-to on understanding gradient elution

A systematic approach for the identification of nontargeted species using nominal and accurate mass data searching both mass spectral and "spectral-less" databases is described.

The detection limit, analytical precision, dynamic range, and robustness of a method for the targeted quantification of peptides using a capillary-flow LC–MS system were evaluated by spiking known amounts of isotopically labeled yeast peptides into a 500-ng yeast digest matrix.

An application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.

The application of high-resolution TOF-MS to petroleomics is presented, and the basic theory of each type of ultrahigh-resolution mass spectral platform is briefly explained.

Leco (Michigan, USA) will support the new West Coast Metabolomics Center, based at the University of California, Davis, Genome Center (California, USA).

Should HPLC eluent additives be added to one or both of the constituent mobile phase reservoirs - both organic and aqueous, when mixing gradients online?

The American Chemical Society (ACS) has announced Brian Bidlingmeyer of Agilent Technologies, Inc. (Santa Clara, California) and a member of LCGC's editorial advisory board to the 2012 class of ACS Fellows.

Click here to read the full Europe E-newsletter from 1 March 2013.

Click the title above to open the LCGC Asia Pacific March 2013 regular issue, Vol 16, No 1, in an interactive PDF format.

Click the title above to open the LCGC Europe March 2013 regular issue, Vol 26 No 3, in an interactive PDF format.

Click the title above to open the LCGC North America March 2013 regular issue, Vol 31 No 3, in an interactive PDF format.

Click the title above to open the March 2013 issue of Current Trends in Mass Spectrometry, Volume 11, Number 1, in an interactive PDF format.

LCGC spoke to Martin Giera of Leiden University Medical Centre, Leiden, The Netherlands, about developments in biomarker discovery.

The amount of vitamin D in supplements can range from 9% to 146% of the stated dose, according to a research letter published in the JAMA Internal Medicine.

In a random study of drugs from 713 pharmacies from 19 countries, 9.1% of anti-tuberculosis drugs analysed failed basic quality control testing using thin layer chromatography (TLC) for the required level of active pharmaceutical ingredient (API), according to a recent study published in the International Journal of Tuberculosis and Lung Disease.1

Click here to view the complete E-Separation Solutions newsletter from February 26, 2013

Thermo EU - GC-MS/MS Analysis of OCPs, PAHs, and PCBs in Environmental Samples