Illegal Migration from Packaging
Consumer protection requires that harmful chemicals are prevented from reaching food products or pharmaceuticals designated for human consumption. Packaging keeps products fresh and protects against direct contamination; however, materials used to manufacture the packaging can be an unintended source of migrating chemicals. To perform routine migration studies, food producers, or packaging suppliers, need to determine barrier properties of primary food packaging.
Consumer protection requires that harmful chemicals are prevented from reaching food products orpharmaceuticals designated for human consumption. Packaging keeps products fresh and protects against directcontamination; however, materials used to manufacture the packaging can be an unintended source of migratingchemicals. To perform routine migration studies, food producers, or packaging suppliers, need to determine barrierproperties of primary food packaging. In the case of pharmaceutical packaging, extractables and leachables studiesare required to determine if contaminants will leach out into the product under normal storage conditions, or, ifcontaminants can be extracted by the product under well-defined, more aggressive conditions. Thermal desorptioncombined with gas chromatography–mass spectrometry (GC–MS) has proven to be an efficient and sensitivescreening method for contaminants in packaging.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
