Application Notes

Sample Prep of Gen-X with WAX/GCB SPE and LC-MS/MS

Microcystins and Nodularin Analysis in Drinking Water by UHPLC-MS/MS for EPA Method 544

Utilizing the concepts of a QuEChERS extraction to prepare the broad range of Pharmaceutical and personal care products (PPCPs) from solid sediment samples for LC-MS/MS analysis

Sample Prep of Gen-X with WAX/GCB SPE and LC-MS/MS

Technote demonstrates high performance LC-MS/MS analysis of trace PFAS in water a large-volume direct injection.

Technote demonstrates analysis of 23 PFASs in less than 5 minutes by UHPLC-MS/MS on a novel 1.6um C18 column chemistry with a positive surface charge to improve performance of the short-chained acids as well.

Potency testing in marijuana-infused edibles is a problematic task due to the complexity of the matrices. The concentration of active ingredients in edibles can range from a few ppm to 3.5% (1). In this application, active cannabinoid compounds were extracted from gummy bears (and also brownies, results not shown), followed by HPLC analysis.

Abuse of synthetic opioid prescription painkillers such as fentanyl, along with a rapidly growing list of illicit analogues, is a significant public health problem. In this study, we developed a simple dilute-and‑shoot method that provides a fast 3.5-min analysis of fentanyl and related compounds in human urine by LC–MS/MS using a Raptor Biphenyl column.

etermination of oligomeric states is an important issue in protein chemistry. For example, self-assembly via oligomerization domains is crucial for the regulation of several protein kinases. Determination of the oligomeric state of fragments of these kinases is a means of verifying the involvement of each domain in self-assembly.

Hallucinogenic mushrooms, known as magic mushrooms, contain psychoactive compounds such as psilocin and psilocybin (Figure 1). This hallucinogenic effect means they are constantly offered on the black market. Therefore, the reliable quantification of these compounds is a particularly important task for forensic analysis because their results have a significant impact on the judgement passed by the courts.

• What are nanoparticles? • spICP-MS for improved nanoparticle characterization and analysis.

Implementing a peptide screening SPE plate determines the appropriate choice for a wide range of chemically diverse peptides.

The optimized dual solid phase extraction (SPE) method was developed to significantly reduce the surfactant background from formulated drug products.

A HILIC solid phase extraction (SPE) and LC method that results in sensitive, effective, and a time savings for the clean-up of N-Glycans.

A fast analytical method including both sample preparation and LC–ƒMS/MS analysis of ibuprofen in human plasma.

Implementing a peptide screening SPE plate determines the appropriate choice for a wide range of chemically diverse peptides.

The optimized dual solid phase extraction (SPE) method was developed to significantly reduce the surfactant background from formulated drug products.

A HILIC solid phase extraction (SPE) and LC method that results in sensitive, effective, and a time savings for the clean-up of N-Glycans.

The development of a selective and rugged LC–MS/MS method for the quantitation of Amlodipine enantiomers in human plasma.

GenX, along with 24 other PFASs, are analyzed simultaneously to achieve sub-ppt reporting limits.

A reliable and efficient method was developed to determine the concentration sterols in olive oil by GC-FID.

The development of a selective and rugged LC–MS/MS method for the quantitation of Amlodipine enantiomers in human plasma.

SPE is used in combination with LC–MS/MS to analyze a panel of opiates from a urine sample.

Mycotoxin in grain are extracted using SPE to removes interferences followed by a rapid LC–MS/MS method.

Mycotoxin in grain are extracted using SPE to removes interferences followed by a rapid LC–MS/MS method.

GenX, along with 24 other PFASs, are analyzed simultaneously to achieve sub-ppt reporting limits.

A fast analytical method including both sample preparation and LC–ƒMS/MS analysis of ibuprofen in human plasma.

SPE is used in combination with LC–MS/MS to analyze a panel of opiates from a urine sample.

Optimize the LC–MS/MS workflow by using a SPE solution that provides in-well urine hydrolysis to save time.

Optimize the LC–MS/MS workflow by using a SPE solution that provides in-well urine hydrolysis to save time.