Application Notes

This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.

Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.

In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.

For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.

In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.

For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.

Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.

Proper filtration is essential for ensuring reliable performance of high performance liquid chromatography (HPLC) instruments. In this ebook, on Modern Filtration Methods for HPLC and UHPLC Sample Preparation, explore: • Tips for mobile phase filtration • Answers to FAQs about syringe filter selection • Why filtration is so important to method development and sample prep • Filters for sample prep in dissolution testing

• Applications of native mass spectrometry • Implementation and technical challenges with native MS

It is important for the standards, organic solvents, and HPLC mobile phases to be of the highest purity, but water quality is often taken for granted.

Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications

Note discusses how labs can streamline operations and cut costs with on-sit gas generation.

• FFF–MALS offers deep and unbiased particle characterization. • Regulatory bodies view FFF–MALS as essential for various nanomedicines.

• Parameter variety adds complexity to analytical method development. • Reversed-phase HPLC offers an efficient approach to simply this process.

• Transferring from HPLC to UHPLC comes with both benefits and costs. • Making the transition more predictable can boost efficiency. • Informed equipment and procedural decisions can combat transfer challenges.

The EAF4 system was used to measure the electrophoretic mobility and zeta potential of 50 nm Ag nanoparticles (AgNPs) coated with three different coating materials.

The EAF4 system was used to measure the electrophoretic mobility and zeta potential of 50 nm Ag nanoparticles (AgNPs) coated with three different coating materials.

Amyloid β proteins are highly hydrophobic and can form aggregates. The analysis of 4 Aβ using YMC-Triart Bio C4 with larger pore and lower hydrophobicity is presented.

In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.

In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.

In this application note we show the separation of charge variants of Trastuzumab under native conditions using a pH gradient formed with volatile buffers.

In this application note we look at a method for determining the level of aggregation in a commercially available sample of intact NIST mAb using a bioZen SEC-2 column together with the SCIEX X500B mass spec.

This application note serves to highlight how native MS can be used to get intact mass for non-covalently linked large molecules, including cysteine linked ADCs

In this application note we show the separation of charge variants of Trastuzumab under native conditions using a pH gradient formed with volatile buffers.

In this application note we look at a method for determining the level of aggregation in a commercially available sample of intact NIST mAb using a bioZen SEC-2 column together with the SCIEX X500B mass spec.

In this application we show the separation of several charge variants of the NIST mAb under native ion exchange and mass spectrometry (high resolution MS) conditions using a pH gradient formed from volatile buffers.

In this application note we show high resolution separation for a suite of protein standards under native mass spec conditions typical for SEC.

In this application note we show high resolution separation for a suite of protein standards under native mass spec conditions typical for SEC.