Application Notes

Amyloid β proteins are highly hydrophobic and can form aggregates. The analysis of 4 Aβ using YMC-Triart Bio C4 with larger pore and lower hydrophobicity is presented.

In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.

In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.

In this application note we show the separation of charge variants of Trastuzumab under native conditions using a pH gradient formed with volatile buffers.

In this application note we look at a method for determining the level of aggregation in a commercially available sample of intact NIST mAb using a bioZen SEC-2 column together with the SCIEX X500B mass spec.

This application note serves to highlight how native MS can be used to get intact mass for non-covalently linked large molecules, including cysteine linked ADCs

In this application note we show the separation of charge variants of Trastuzumab under native conditions using a pH gradient formed with volatile buffers.

In this application note we look at a method for determining the level of aggregation in a commercially available sample of intact NIST mAb using a bioZen SEC-2 column together with the SCIEX X500B mass spec.

In this application we show the separation of several charge variants of the NIST mAb under native ion exchange and mass spectrometry (high resolution MS) conditions using a pH gradient formed from volatile buffers.

In this application note we show high resolution separation for a suite of protein standards under native mass spec conditions typical for SEC.

In this application note we show high resolution separation for a suite of protein standards under native mass spec conditions typical for SEC.

This application note serves to highlight how native MS can be used to get intact mass for non-covalently linked large molecules, including cysteine linked ADCs

Combining the efficient immunocapture and sample extraction of bioZen MagBeads, trastuzumab is isolated from rat plasma to yields greater selectivity relative to traditional ligand-binding assays.

Combining the efficient immunocapture and sample extraction of bioZen MagBeads, trastuzumab is isolated from rat plasma to yields greater selectivity relative to traditional ligand-binding assays.

In this application, Streptavidin coated bioZen MagBeads are utilized for the fast and accurate immunocapture of insulin aspart novolog. By combining immunocapture sample preparation with LC MS/MS, this method demonstrates a functionalized assay that yields greater selectivity and sensitivity.

In this application, Streptavidin coated bioZen MagBeads are utilized for the fast and accurate immunocapture of insulin aspart novolog. By combining immunocapture sample preparation with LC MS/MS, this method demonstrates a functionalized assay that yields greater selectivity and sensitivity.

In this application we show the separation of several charge variants of the NIST mAb under native ion exchange and mass spectrometry (high resolution MS) conditions using a pH gradient formed from volatile buffers.

This study shows the advantages of automated immersive sorptive extraction for the GC–MS analysis of a wide range of aroma compounds in vodka.

This study shows the advantages of automated immersive sorptive extraction for the GC–MS analysis of a wide range of aroma compounds in vodka.

This application note demonstrates how sensitive UV detection provides quantitation of a genotoxic impurity at low ng/mL level.

This application note demonstrates how sensitive UV detection provides quantitation of a genotoxic impurity at low ng/mL level.

This application note describes workflow for the simultaneous quantitative analysis of fat-soluble and water-soluble vitamins in drinks and food supplement tablets.

This application note demonstrates how sensitive UV detection provides quantitation of a genotoxic impurity at low ng/mL level.

This application note describes workflow for the simultaneous quantitative analysis of fat-soluble and water-soluble vitamins in drinks and food supplement tablets.

This application note demonstrates how sensitive UV detection provides quantitation of a genotoxic impurity at low ng/mL level.

This application note demonstrates the capabilities for Dual LC to run independent HPLC and UHPLC methods simultaneously using one instrument.

The Thermo Scientific Vanquish Duo system for Dual employs two separate flow paths for simultaneous analysis of complex samples.

This application note demonstrates the capabilities for Dual LC to run independent HPLC and UHPLC methods simultaneously using one instrument.

The Thermo Scientific Vanquish Duo system for Dual LC can run two methods simultaneously on one instrument, regardless if identical chromatographic conditions are used.

The Thermo Scientific Vanquish Duo system for Dual LC enables two sample runs concurrently, so samples to run in half the time, improving pharmaceutical drug analysis.