What’s in a Method
LCGC Europe
John Hinshaw asks what constitutes a chromatographic method and addresses some of the issues that method transfer raises for method documentation and validation.
Profiling Volatile Organic Compounds in Whisky with GC×GC–MS
November 1st 2024Researchers from Austria, Greece, and Italy conducted a study to analyze volatile organic compounds (VOCs) present in Irish and Scotch whiskys using solid-phase microextraction (SPME) Arrow with comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC–MS) to examine the organoleptic characteristics that influence the taste of spirits.
GC–TOF-MS Finds 250 Volatile Compounds in E-Cigarette Liquids
November 1st 2024A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.
GC–MS Targeted Analysis of PFAS Helps Expand Knowledge of Toxicokinetic Data
November 1st 2024Limited toxicokinetic and toxicologic information is available about a diverse set of per- and polyfluoroalkyl substances (PFAS), but methods based on gas chromatography–tandem mass spectrometry (GC–MS/MS) can help unravel some of the mystery.
Multivariate Design of Experiments for Gas Chromatographic Analysis
November 1st 2024Recent advances in green chemistry have made multivariate experimental design popular in sample preparation development. This approach helps reduce the number of measurements and data for evaluation and can be useful for method development in gas chromatography.
