This article discusses GPC and gives examples of the use of the technique in excipient analysis.
New philosophies in pharmaceutical industry such as Quality by Design (QbD) require a detailed understanding of the properties and behaviour of drug components, including polymeric excipients such as binders and disintegrants. Gel permeation chromatography (GPC, also known as size exclusion chromatography) is a vital tool for investigating the behaviour of polymers, and is increasingly employed in pharmaceutical laboratories to investigate macromolecules. This article discusses GPC and gives examples of the use of the technique in excipient analysis.
Separating Impurities from Oligonucleotides Using Supercritical Fluid Chromatography
February 21st 2025Supercritical fluid chromatography (SFC) has been optimized for the analysis of 5-, 10-, 15-, and 18-mer oligonucleotides (ONs) and evaluated for its effectiveness in separating impurities from ONs.