Understanding the Behaviour of Pharmaceutical Polymers
This article discusses GPC and gives examples of the use of the technique in excipient analysis.
New philosophies in pharmaceutical industry such as Quality by Design (QbD) require a detailed understanding of the properties and behaviour of drug components, including polymeric excipients such as binders and disintegrants. Gel permeation chromatography (GPC, also known as size exclusion chromatography) is a vital tool for investigating the behaviour of polymers, and is increasingly employed in pharmaceutical laboratories to investigate macromolecules. This article discusses GPC and gives examples of the use of the technique in excipient analysis.
USP CEO Discusses Quality and Partnership in Pharma
December 11th 2024Ronald Piervincenzi, chief executive officer of the United States Pharmacoepia, focused on how collaboration and component quality can improve worldwide pharmaceutical production standards during a lecture at the Eastern Analytical Symposium (EAS) last month.
Overcoming Common Challenges to Determine Residual Impurities Using IC in APIs with Limited Water
December 10th 2024Organic solvents are generally not compatible with ion chromatography (IC) systems. The approach presented here assists the use of organic solvents for sample preparation and provides a mechanism for the removal of the organic solvents from the chromatographic flow path.
