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Comparison of fully and superficially porous particle columns for the analysis of basic compounds
May 15th 2009The goal of this work is to investigate the differences in separation performance between fully and superficially porous particle columns for routine analysis of basic pharmaceutical drug compounds. Major parameters of comparison are chemical stability, peak capacity and column efficiency at different mass loads.
Mass spectrometry company acquired
May 13th 2009PerkinElmer has acquired mass spectrometry equipment supplier Analytica of Branford. The acquisition, the terms of which were not disclosed, is an integral part of PerkinElmer's strategic commitment to continue to grow its human and environmental health portfolio.
Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation
May 8th 2009Varian, Inc. has published an application note entitled Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation. This note shows that the Varian ELSD surpasses other ELSDs for low temperature HPLC applications with semi-volatile compounds.
TSKgel NH2-100 — a new, robust HILIC column
May 8th 2009Tosoh Bioscience publishes an application note on vitamin analysis with the new, amino-type TSK–GEL HILIC column that was recently launched. It shows high stability and is well suited for all separations requiring amino functional groups. More information on www.tskgel.com
Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation
May 4th 2009Parabens (esters of para-benzoic acid) are widely used as food additives and synthetic preservatives in cosmetics and personal care products, and in pharmaceutical formulations. Common types include methyl paraben (E218), ethyl paraben (E214) and propyl paraben (E216).
Therapeutic Diazepam Monitoring in Human Plasma and Urine by HPLC: An Application for Alcoholism
May 4th 2009The 1,4-benzodiazepines constitute an important class of psychotherapeutic agents known for their hypnotic, tranquilizing and anti-convulsant properties. Comprehensive research has been performed to study their clinical performance (1).
9th Annual Csaba Horvath Symposium
May 4th 2009At a time when the conference and symposium industry seems to be dominated by giants such as Pittcon and ASMS, it is refreshing to find a thriving boutique conference like the 9th Annual Csaba Horvath Symposium held April 28?29 at the Hartford Convention Center in Hartford, Connecticut.
Response Surface Designs Part 1 — Types and Properties
May 1st 2009Experimental designs are used in method development and robustness testing and have been discussed in an earlier article.1 An experimental design is an experimental set-up that allows the simultaneous examination of a predefined number of factors in a predefined number of experiments. Method development is often divided into a screening and an optimization step. During the first step, many factors, potentially affecting the method, are screened to determine the most important factors, which are then further optimized.1
Using Two-dimensional Liquid Chromatography to Separate Complex Mixtures of Peptides
May 1st 2009Two-dimensional liquid chromatography (2D-LC) allows analysts to deal with complex samples that either cannot be adequately separated by one-dimensional liquid chromatography (1D-LC) or require excessively long analysis times. Peptide mixtures, whose characterization is relevant in many areas (e.g., proteomics, food analysis, pharmaceutical, life sciences), are a clear example of such complexity. An overview of the most used 2D-LC modes of operation is presented and several examples of their use for the separation of peptide mixtures are described.
