Current Trends in Mass Spectrometry
A Novel Mass Spectrometry Paradigm to Analyze Classical and New Biotherapeutic Modalities
May 1st 2023A new fragmentation approach—tunable electron-activated dissociation (EAD) tandem mass spectrometry (MS/MS)—offers a solution to better improve the detection and characterization of impurities in lipid nanoparticles and impurities in other biopharmaceutical modalities.
An LC–MS/MS Method for the Evaluation of Intestinal Permeability in Blood Plasma
May 1st 2023A rapid and robust LC–MS/MS method for determining lactulose and rhamnose concentrations in blood plasma was used to determine intestinal permeability from blood plasma, which can help diagnose gastrointestinal diseases such as Crohn’s disease.
Demystifying Sample Preparation for Headspace Analysis Using Direct Injection Mass Spectrometry
May 1st 2023Direct-injection mass spectrometry (DIMS) and gas chromatography (GC) approaches have some significant differences that are pertinent when analyzing volatile organic compounds (VOCs). We explain.
Analysis of PFAS in Locally Acquired Food Containers
May 1st 2023The combination of an untargeted approach using ultrahigh pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF) and a targeted approach using UHPLC–tandem mass spectrometry (MS/MS) are presented as an ideal method for detecting per- and polyfluroalkyl substances (PFAS) in fast-food packaging.
