Advances in LC Column Technology

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Chromatographic Comparison of HILIC Stationary Phases Prepared Using Various Hydrophilization Techniques

Alla Chernobrovkina
April 1st 2023
Events

This comparison of various silica-based HILIC stationary phases with different types of coatings provides a better understanding of how stationary phase selectivity can be influenced.

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Insights into the Shape-Selective Retention Properties of Porous Graphitic Carbon Stationary Phases and Applicability for Polar Compounds

Clinton Corman;Cory E. Muraco;Michael Ye;Frank Michel
April 1st 2023
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When the unique shape-selective properties of PGC are appropriately identified, PGC stationary phases can be harnessed for fine separations of structurally related compounds.

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Combining Different Stationary-Phase Chemistries to Improve the Selectivity of Impurity Profiling Methods

Róbert Kormány;Krisztián Horváth;Szabolcs Fekete
April 1st 2023
Article

Serial coupling of different column types can provide several important benefits to the chromatographer, including fine-tuning selectivity to separate complex mixtures.

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Pressure–Enhanced Liquid Chromatography as a Suitable Approach to Improve Selectivity for Large Molecule Separations

Honorine Lardeux;Davy Guillarme;Mateusz Imiołek;Szabolcs Fekete;Matthew A. Lauber
April 1st 2023
Article

Pressure-enhanced liquid chromatography (PE-LC) offers a new approach for improving selectivity for large molecule separations. Examples shown here include short oligonucleotides in ion-pairing reversed-phase (IP-RP) liquid chromatography and larger nucleic acids in ion-exchange (IEX) chromatography.