Investigating Alzheimer’s Using UHPLC–MS
April 25th 2016Researchers from Heilongjiang University of Chinese Medicine, China, have used ultrahigh-performance liquid chromatography coupled to mass spectrometry and metabolomics to investigate the metabolic networks of Alzheimer’s disease, identifying potential biomarkers and biochemical mechanisms.
Low-Pressure GC and UHPLC Analysis of Environmental Contaminants in Meats
April 11th 2016A team of researchers has developed a high‑throughput analysis method for 192 diverse pesticides and 51 environmental contaminants in cattle, swine, and poultry meats. The team used a combination of low-pressure gas chromatography coupled to tandem mass spectrometry (LP)GC–MS–MS and ultrahigh-pressure liquid chromatography coupled to tandem MS in the analysis.
Characterizing New Psychoactive Substances
April 11th 2016Researchers from the Joint Research Centre of the European Commission have published a case study detailing the characterization of new psychoactive substances using gas chromatography–mass spectrometry, nuclear magnetic resonance, high‑resolution tandem mass-spectrometry, and Raman spectroscopy.
Schoenmakers Awarded 2.5 Million Euros for “A Million Peaks” Project
April 6th 2016Peter Schoenmakers of the University of Amsterdam has been awarded a prestigious grant worth 2.5 million Euros by the European Research Council to develop new high-performance separation technology. The grant will fund Schoenmakers’s research project “Separation Technology for A Million Peaks” (STAMP).
Matthew Miller Wins the Satinder Ahuja Award for Young Investigator in Separation Sciences
March 23rd 2016The Satinder Ahuja Award for Young Investigator in Separation Sciences has been presented to Matthew Miller, Technical Leader at Dow Chemical in the Analytical Science Core R&D group, at Pittcon 2016.
Quantifying Nicotine Levels in Necrophagous Insects Using GC–MS
March 9th 2016Researchers studying necrophargous blowflies for forensic investigations have developed a novel gas chromatography–mass spectrometry (GC–MS) method for the detection of nicotine. Nicotine has been attributed to a number of accidental or sudden, suicidal, and homicidal deaths.
Discovering the Drug Habits of Nightclubbers and Criminals Using UHPLC
February 22nd 2016The Norwegian Institute of Public Health conducted a study into the drug use habits of nightclubbers and arrested criminals in Oslo, Norway. The study used UHPLC–MS–MS to analyze the drug-use profiles of nightclubbers and criminals arrested while under the influence of drugs to develop an understanding of drug use patterns in these groups.
Compositional Analysis of Honeybee Venom for Proteomics
February 22nd 2016Research into honeybee venom is being performed to identify active proteins acting as allergens and toxins. Researchers combined LC–MALDI-TOF/TOF-MS–MS, LC–ESI-QTOF-MS–MS, and a combinatorial peptide ligand library enrichment method to detect 269 proteins.
Can SBWC Replace HPLC in Pharmaceutical Analysis?
February 17th 2016Subcritical water chromatography (SBWC) is seen as an increasingly enticing prospect to replace high performance liquid chromatography (HPLC) in industrial settings because of its low costs and environmental impact. Yu Yang of East Carolina University, in Greenville, North Carolina, USA, has conducted research into this process for two decades. He recently spoke to LCGC about his work, why companies should consider SBWC, and its role in pharmaceutical analysis.
Detection Markers in Trypanosomiasis
February 8th 2016Researchers from Imperial College London and the University of Aberdeen have identified disease markers for Human African Trypanosomiasis (HAT), commonly known as “sleeping sickness”. Using reversed-phase ultrahigh‑performance liquid chromatography coupled to mass spectrometry (UHPLC–MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy researchers found 53 discriminatory metabolite markers.
Pattern Modulation Offers Alternative to Pulse Modulation in GC×GC
January 19th 2016New research into flow modulation methods in valve-based two-dimensional gas chromatography (GC×GC) has produced an effective alternative to traditional pulse modulation.1 Described as “pattern modulation”, this new method increases effluent to the secondary column with flow rates compatible with most chromatographs and spectrometers.
Off-Line NMR Improves Traditional Chinese Medicine Analysis
November 23rd 2015Researchers at Zhejiang University, China, have developed a new method combining liquid chromatography-mass spectrometry (LC-MS) and off-line nuclear magnetic resonance (NMR) to analyze the constituents within traditional Chinese medicines (TCMs).
Screening Procedure for “Non Banned” Drugs
November 23rd 2015A new screening procedure has been developed for the detection of common “non banned” drugs used by athletes. The method targets multiple pharmacologically active compounds by liquid chromatography-electrospray ionization coupled to tandem mass spectrometry (LC-ESI-MS-MS).