David S. Bell
Dr. David S. Bell is currently Lead Consultant and Owner at ASKkPrime, LLC a consulting firm focused in the separation science arena. Dave also serves on the Editorial Advisory Board for LCGC Magazine and is the Editor for the Column Watch series of articles.
Over the past three decades, Dave has worked directly in the chromatography industry, focusing his efforts on the design, development, and application of chromatographic stationary phases to advance gas chromatography, liquid chromatography, sample preparation and related hyphenated techniques.Prior to focusing on chromatography device development and application, he spent a decade immersed in the pharmaceutical industry performing analytical method development and validation employing various forms of chromatography and electrophoresis.
Dave’s main objectives have been to create and promote novel chromatography technologies and to conduct and collaborate on research aimed toward understanding molecular interactions that contribute to retention and selectivity in an array of chromatographic processes. His research results have been presented in hundreds of symposia worldwide, and have resulted in more than 95 peer-reviewed journal and trade magazine articles.His efforts have also contributed to the development and commercialization of numerous products utilized in laboratories worldwide.
Dave’s undergraduate studies in chemistry were completed at the State University of New York at Plattsburgh (SUNY Plattsburgh). He earned his PhD in Chemistry from The Pennsylvania State University (State College, Pennsylvania).
Articles
Mechanisms of Interaction Responsible for Alternative Selectivity of Fluorinated Stationary Phases
February 1st 2016Fluorinated stationary phases, especially those including a pentafluorophenyl (PFP) moiety, have become popular alternatives to the more traditional alkyl (C8 and C18) phases. Many modern column lines have, in fact, been initially introduced with the standard C18 and a PFP phase because of their orthogonality. In this instalment, the differences between alkyl phases and PFP phases are discussed in terms of fundamental interactions. The origin of the interactions is also interpreted to better understand how analysts can use and control them to develop effective and rugged analytical methods.
Retention and Selectivity of Stationary Phases Used in HILIC
November 1st 2015Hydrophilic-interaction chromatography (HILIC) is a complex system involving partition, polar, and ion‑exchange interactions. Method development can be greatly facilitated by understanding the interactions that the different stationary phases provide and applying that knowledge to the separation task at hand. Through an understanding of the main differences of the set of analytes to be separated, a column or set of columns can be judiciously chosen to screen for effective retention and selectivity.
Highlights from the HPLC 2015 Symposium
September 1st 2015HPLC 2015, chaired by Gérard Hopfgartner was held in Geneva, Switzerland, from June 21–25. This installment covers some of the highlights observed at the symposium including stationary phase developments, particle technology, and areas of growing application of HPLC. In addition, trends and perspectives on future developments in HPLC culled from the conference are presented.
Highlights from the HPLC 2015 Symposium
September 1st 2015The 42nd International Symposium of High Performance Liquid Phase Separations and Related Techniques (HPLC 2015), chaired by Gérard Hopfgartner was held 21–25 June in Geneva, Switzerland. This instalment covers some of the highlights observed at the symposium including stationary-phase developments, particle technology, and areas of growing application of HPLC. In addition, trends and perspectives on future developments in HPLC culled from the conference are presented.
Highlights from the HPLC 2015 Symposium
September 1st 2015The 42nd International Symposium of High Performance Liquid Phase Separations and Related Techniques (HPLC 2015), chaired by Gérard Hopfgartner was held 21–25 June in Geneva, Switzerland. This instalment covers some of the highlights observed at the symposium including stationary-phase developments, particle technology, and areas of growing application of HPLC. In addition, trends and perspectives on future developments in HPLC culled from the conference are presented.
Current State of Superficially Porous Particle Technology in Liquid Chromatography
June 10th 2015The use of superficially porous particles (SPPs) in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology. At the recent Pittcon conference in New Orleans, Louisiana, USA, a large number of oral and poster presentations centred on the current research and advances using superficially porous particles. This instalment aims to provide some highlights of these recent trends.
Current State of Superficially Porous Particle Technology in Liquid Chromatography
June 1st 2015The use of superficially porous particles in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology.
Fast and Accurate LC–MS Analysis of Vitamin D Metabolites Using Ascentis® Express F5 HPLC Columns
June 1st 2011Vitamin D deficiency has become a topic of interest in recent publications (1–3). Vitamin D is present in two forms, Vitamin D3 and Vitamin D2. D3 is produced after ultraviolet light-stimulated conversion of 7-dehydrocholesterol in the skin (3).
