Recent Developments in Ion-Exchange Columns for Inorganic Ions and Low Molecular Weight Ionizable Molecules
Special Issues
Ion exchange is one of the older of the chromatographic techniques yet each year new products continue to hit the market. In this paper, Chris Pohl of Dionex will summarize some of the stationary phases that have been developed for modern ion-exchange and ion chromatography. He will focus on phase design and then turn his attention to new anion and cation columns introduced in the last couple of years.
New Study Examines PFAS in Breast Milk Using LC-MS/MS
November 5th 2024On the suggestion that per- and polyfluoroalkyl substances (PFAS) affect both lactation and the human metabolome, perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were measured in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
