Pittcon (Pittsburgh, Pennsylvania) announced that twelve sessions at Pittcon 2009 at McCormick Place South in Chicage, March 8-13, will be coprogrammed with the ACS Division of Analytical Chemistry (ACS-DAC).
Pittcon (Pittsburgh, Pennsylvania) announced that twelve sessions at Pittcon 2009 at McCormick Place South in Chicago, March 8–13, will be coprogrammed with the ACS Division of Analytical Chemistry (ACS-DAC). The planned sessions include invited symposia, organized contributions, and a poster session. Topics will include the biological applications of capillary electrophoresis, the evolution of modern chromatography, HPLC method robustness, multidimensional separations, pressurized fluids in separations technology, a young investigator award, validation of bioanalytical methods, electrochemical sensors, pesticide analysis, sub-2-μm particles and chromatography, and quality assurance.
Determining Neurotransmitters in Spinal Cords with UHPLC
February 18th 2025Researchers at Jilin University (Changchun, China) developed a highly sensitive, rapid, and accurate method for analyzing neurotransmitters (NTs) in rat spinal cord tissue. Ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS) in conjunction with ultra-ionic liquid dispersive liquid-liquid microextraction (UA-MIL-DLLME) were used to extract NTs for analysis.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
Revolutionizing LC-MS with Next-Gen Separation for Cyclic Peptide Analysis
February 17th 2025Cyclic peptides, known for their stability and high specificity, are promising therapeutic agents in the fight against cancer, infections, and autoimmune diseases. However, developing effective cyclic peptides presents numerous challenges, including poor pharmacokinetics, efficacy, and toxicity. Traditional methods like liquid chromatography tandem-mass spectrometry (LC-MS/MS) often struggle with resolving isomeric linear peptide metabolites, posing significant risks in safety, efficacy, and regulatory approval. In this paper, Komal Kedia, PhD, will share how she leveraged MOBIE’s high-resolution ion mobility-mass spectrometry (IM-MS) system to achieve a 72% reduction in run times, 200% greater resolving power, and enhanced accuracy in identifying “soft spots” prone to enzymatic degradation.