Market Profile: UHPLC
Market Profile: UHPLC
Ultrahigh-performance liquid chromatography (UHPLC) systems are designed to take full advantage of smaller particles (sub 2 μm), which yield higher resolution and increased sensitivity. Because of increased back pressure, UHPLC systems employ high-performance pumps that deliver 15 000 psi (1,000 bar) or more of pressure. Some systems solve the back-pressure issue by elevating temperatures using a column oven, which lower the viscosity of the mobile phase, allowing it to move faster through the column. UHPLC systems have been shown to provide analysis times of less than 1 min and up to 40 times faster than conventional HPLC systems.
Regulatory Deadlines and Supply Chain Challenges Take Center Stage in Nitrosamine Discussion
April 10th 2025During an LCGC International peer exchange, Aloka Srinivasan, Mayank Bhanti, and Amber Burch discussed the regulatory deadlines and supply chain challenges that come with nitrosamine analysis.
New Study Investigates Optimizing Extra-Column Band Broadening in Micro-flow Capillary LC
March 12th 2025Shimadzu Corporation and Vrije Universiteit Brussel researchers recently investigated how extra-column band broadening (ECBB) can be optimized in micro-flow capillary liquid chromatography.
