The Column
Glycoprotein monosaccharide compositional analysis is important for the development and manufacture of glycoprotein human therapeutics. Here we report a robust method for this analysis. This chromatographic method requires no mobile phase preparation thus saving time and delivering excellent retention time reproducibility that results in good method reproducibility.
Glycoprotein monosaccharide compositional analysis is important for the development and manufacture of glycoprotein human therapeutics. Here we report a robust method for this analysis. This chromatographic method requires no mobile phase preparation thus saving time and delivering excellent retention time reproducibility that results in good method reproducibility.
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Exploring Metabolite Alteration from Age-Related Macular Degeneration with UHPLC-MS/MS
February 19th 2025Exploring the alterations in metabolites of wet age-related macular degeneration (wAMD), metabolomic analysis was performed on the aqueous humor of 30 patients with wAMD receiving anti-vascular endothelial growth factor (anti-VEGF) treatments and 20 controls, via ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.