Sample clean-up using solid-phase extraction (SPE) and similar methods can sometimes be both time-consuming and expensive. The purification of complex plant extracts requires special care in particular. A robust and sensitive online SPE sample preparation method is described for the determination of steviol glycosides.
Sample clean-up using solid-phase extraction (SPE) and similar methods can sometimes be both time-consuming and expensive. The purification of complex plant extracts requires special care in particular. A robust and sensitive online SPE sample preparation method is described for the determination of steviol glycosides.
A Novel Two-Step Workflow for Extracting Clean Mass Spectra in LC×LC–HRMS Data
March 3rd 2025LCGC International spoke to Paul-Albert Schneide and Oskar Munk Kronik about the development and application of a novel two-step workflow—mass filtering (MF) combined with multivariate curve resolution (MCR)—for extracting clean mass spectra from trace-level compounds in LC×LC–HRMS data.
Predicting Retention Indices in LC–HRMS to Improve Water Quality Analysis
February 21st 2025Ardiana Kajtazi discusses her research identifying organic micropollutants in water using liquid chromatography–high-resolution mass spectrometry (LC–HRMS). She highlights the standardized filtration approach her team has developed based on intersection principles, utilizing retention indices from two reversed-phase liquid chromatography (RPLC) columns.