Exploring the Application of MALDI-IHC with Bottom-up Proteomics: An ASMS Interview with Ron Heeren

Heeren spoke with us at ASMS 2023 in Houston, Texas, where he briefed us on his current research endeavors that involve using multiplexed matrix-assisted laser desorption/ionization–immunohistochemistry (MALDI-IHC) with image-guided proteomics to further investigate diseases. The idea is that MALDI-IHC with image-guided proteomics can provide information from the same tissue section without the need for customized and complex instrumentation.

Heeren is a Distinguished Professor and and Limburg co-chair of the Maastricht Multimodal Molecular Imaging Institute in the Division of Imaging Mass Spectrometry at Maastricht University.

In this video interview, Heeren answers the following questions:

1. How does MALDI-IHC combine MALDI mass spectrometry imaging and immunohistochemistry for targeted tissue imaging?
2. What advantages does MALDI-IHC offer over traditional IHC in studying specific biomolecules in tissues?
3. What insights can be gained from integrating MALDI-IHC with bottom-up proteomics in breast cancer research?
4. How can MALDI-IHC and image-guided proteomics contribute to disease understanding and the development of new approaches?
5. What are the next steps in a future study on this subject?

Our interview with Heeren was one of several conducted live at ASMS 2023. Stay tuned for our other interviews conducted at ASMS.