Agilent Joins AMBIC to Advance Biomanufacturing
Agilent Technologies Inc. (California, USA) has announced that it has become a member of the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC), to demonstrate the company’s commitment to partnering to support the provision of the next generation of analytical tools and comprehensive solutions needed by academic, pharmaceutical, and clinical researchers. “Our customers recognize the need to improve biotherapeutic manufacturing,” said Darlene Solomon, Senior VP and CTO at Agilent. “Working with AMBIC we look forward to advancing technologies.” There is a growing need to rapidly assess critical process and product quality attributes to support biotherapeutics manufacturing and facilitate adaptive process controls. AMBIC brings together leading academic and industrial biotechnologists, who are focused on mammalian cell culture manufacturing.
Its mission is to develop enabling technologies, knowledge, design tools, and methods that apply and integrate high-throughput and genome-based technologies to fast-track advanced biomanufacturing processes. Through systems-level biology analysis, novel cell‑line development, bioreactor optimization, and advanced analytics, AMBIC aims to provide transformative solutions that can lower biomanufacturing costs and improve bioprocessing efficiency. For more information, please visit: www.ambic.org
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
LC/MS Based Characterization Workflow of GLP-1 Therapeutic Peptide Liraglutide and Its Impurities
January 14th 2025This application note demonstrates a liquid chromatography/quadrupole time-of-flight mass spectrometer (LC/Q-TOF MS) workflow for the identification and characterization of therapeutic peptides.
