Agilent Technologies Inc. (California, USA) has announced that it has become a member of the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC), to demonstrate the company’s commitment to partnering to support the provision of the next generation of analytical tools and comprehensive solutions needed by academic, pharmaceutical, and clinical researchers. “Our customers recognize the need to improve biotherapeutic manufacturing,” said Darlene Solomon, Senior VP and CTO at Agilent. “Working with AMBIC we look forward to advancing technologies.” There is a growing need to rapidly assess critical process and product quality attributes to support biotherapeutics manufacturing and facilitate adaptive process controls. AMBIC brings together leading academic and industrial biotechnologists, who are focused on mammalian cell culture manufacturing.
Its mission is to develop enabling technologies, knowledge, design tools, and methods that apply and integrate high-throughput and genome-based technologies to fast-track advanced biomanufacturing processes. Through systems-level biology analysis, novel cell‑line development, bioreactor optimization, and advanced analytics, AMBIC aims to provide transformative solutions that can lower biomanufacturing costs and improve bioprocessing efficiency. For more information, please visit: www.ambic.org
An LC–HRMS Method for Separation and Identification of Hemoglobin Variant Subunits
March 6th 2025Researchers from Stanford University’s School of Medicine and Stanford Health Care report the development of a liquid chromatography high-resolution mass spectrometry (LC–HRMS) method for identifying hemoglobin (Hb) variants. The method can effectively separate several pairs of normal and variant Hb subunits with mass shifts of less than 1 Da and accurately identify them in intact-protein and top-down analyses.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.