Get the Most Out of Narrow-Bore GC Columns with Intermediate-Volume (IV) Liners
The benefits of high-efficiency, narrow-bore GC columns are limited by sample transfer onto the column, but this step can now be optimized using Restek’s intermediate-volume (IV) inlet liners. With higher sample capacity than smaller volume liners and faster sample transfer than larger volume liners, new IV liners produce fast, sensitive, and highly reproducible results. The more balanced performance improves chromatography, making peak identification and quantitation easier and more accurate. In addition, the short residence time in the inlet protects against band broadening and analyte breakdown during splitless injection. Explore our IV liner applications for semivolatiles, PAHs, and pesticides and see how to get the most out of narrow-bore GC columns!
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The Next Frontier for Mass Spec: Maximizing Ion Utilization
January 20th 2025MOBILion has introduced a new high-resolution mass spectrometry (HRMS) approach that can increase speed and sensitivity in omics applications. The parallel accumulation with mobility aligned fragmentation (PAMAF) approach substantially increases the fraction of ions used for MS analysis by replacing the functionality of the quadrupole with high-resolution ion mobility.
The Intricacies of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
