TESTA Analytical COMBO-TWO MALS/DRI Combination Detector
TESTA Analytical reports how its COMBO-TWO MALS/DRI combination detector for Gel Permeation Chromatography (GPC) is helping biopharmaceutical and advanced materials researchers unlock essential macromolecular physical properties including molecular weight, structure, and conformation.
The baseline signal stability of any GPC detector is important, as it is a limiting factor in peak determination. Combining a high-performance 7-angle Multi-Angle Light Scattering (MALS) and an ultra-stable Differential Refractive Index (DRI) detector that operate at the same wavelength with minimal delay volume, COMBO–TWO delivers exceptional results.
The COMBO-TWO is fully compatible with all commercial GPC systems and has high thermal stability, operating from room temperature up to 80°C. Obtaining highly accurate and reliable MALS and DRI data is simple – just inject your sample into the low-volume flow cell.
Carlo Dessy, technical director of TESTA Analytical, said, “The outstanding stability of our COMBO-TWO detector package is particularly essential for high-resolution GPC applications which can have separation times of up to one hour.” He added, “Our customers also appreciate the broad media compatibility of the detectors, and their built-in automatic cell-safety shut off capability that eliminates the possibility of a GPC flow cell bursting if it becomes blocked."
For further information about the COMBO-TWO please visit https://www.testa-analytical.com/gpc-sec-chromatography.html or contact TESTA Analytical on +49-30-864-24076 / info@testa-analytical.com.
TESTA Analytical is a leading specialist supplier of liquid chromatography instruments and detectors. Drawing upon over 30 years’ experience, TESTA Analytical has established itself as a respected creator and supplier of top quality, innovative, high performance chromatography instrument kits, and detectors with end user and OEM clients around the world.
The Next Frontier for Mass Spec: Maximizing Ion Utilization
January 20th 2025MOBILion has introduced a new high-resolution mass spectrometry (HRMS) approach that can increase speed and sensitivity in omics applications. The parallel accumulation with mobility aligned fragmentation (PAMAF) approach substantially increases the fraction of ions used for MS analysis by replacing the functionality of the quadrupole with high-resolution ion mobility.
The Intricacies of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
