M.S. Tswett and the Invention of Chromatography
Leslie Ettre discusses the life and activities of the inventor of chromatography.
Breaking Down Barriers: Can LC–MS Revolutionize the Quantitation of Drug Product Impurities?
The authors test and compare performance of three types of LC–MS systems for precision, linearity, selectivity, accuracy, and sensitivity in the quantitation of drug impurities.
GC Instruments and Accessories at the 54th Pittsburgh Conference
The authors describe GC product introductions at Pittcon 2003.
Comparison of an Evaporative Light-Scattering Detector and a Chemiluminescent Nitrogen Detector for Analyzing Compounds Lacking a Sufficient UV Chromophore
The authors discuss the advantages and disadvantages of evaporative light-scattering detection and chemiluminescent nitrogen detection for determining compounds lacking UV chromophores.
New Chromatography Columns and Accessories at the 2003 Pittsburgh Conference, Part II
The conclusion of a two-part series in which Ron Majors examines the trends in column introduction at Pittcon 2003.
An Organic Solvent–Free Method for Determining Oxytetracycline in Cow's Milk
This article presents an organic solvent–free method for the determination of oxytetracycline residue in cow's milk using HPLC.
Interactions of Enantiomers of Aromatic Amino Acids with Highly Sulfated Cyclodextrins
The author reports a comparative study of the interaction of aromatic amino acids with a class of highly sulfated cyclodextrins as the chiral selectors by capillary electrophoresis.
GC Troubleshooting — A Troubleshooter's Tool Kit
John Hinshaw examines the tools and accessories that gas chromatographers use in their laboratories.
Flow Rate and Peak Spacing
Flow-rate changes might or might not be acceptable means to adjust retention.
Critical Pairs in Column Chromatography: A Primer for Pharmaceutical Method Validation
This article reviews several common applications of the critical-pair approach to column chromatography as it is applied under pharmaceutical guidelines and validation strategies.
Handling Fast Peaks
John Hinshaw examines the effects of system time constants and sampling rates on apparent peak shapes and areas.
New Chromatography Columns and Accessories at the 2003 Pittsburgh Conference, Part I
The first of two columns about new chromatography columns, accessories, and sample preparation products introduced at Pittcon 2003.
LC Columns — The Top-10 List
John Dolan provides 10 tips for the proper care and use of LC columns.
Validation of Bioanalytical Methods — Highlights of FDA's Guidance
This column explores and highlights recently published guidelines for bioanalytical method validation.
The Thermally Tuned Tandem Column Approach to Optimizing Selectivity in HPLC
The authors compare thermally tuned tandem column separations with single-column optimization strategies.
Preparing the Laboratory for a Gas Chromatograph
John Hinshaw examines basic laboratory heating, ventilation, cooling, electrical, and space requirements for the successful installation of a gas chromatograph.
Pittcon Product Showcase
Products and literature for separation science.
Success with Evaporative Light-Scattering Detection
Craig Young and John Dolan provide tips and techniques for evaporative light-scattering detection.
Mobile-Phase Cleanup Using Solid-Phase Extraction Disks
The authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
Two Early, Influential Symposia in the Development of Gas Chromatography
"Milestones in Chromatography" discusses the beginnings of gas chromatography in the UK and the first two international symposia that played an important role in the dissemination of the technique.
November Events
Events for November 2003...
A GC–MS Purge-and-Trap Method Comparison Study for MTBE Analysis in Groundwater
This article describes a study that assesses the ability of commercially available GC–MS methods to meet project criteria for MTBE in groundwater matrices.
More Peak Asymmetry Calculation
Leslie Ettre discusses peak asymmetry calculation.
The Cleaning and Regeneration of Reversed-Phase HPLC Columns
Ron Majors looks at practical ways to return a contaminated column to its original state.
GC Analysis of Trihalomethanes in Drinking Water — A Rapid and Direct Quantitative Method
The authors describe a GC assay of trihalomethanes in drinking water.
Mobile-Phase Buffers, Part III — Preparation of Buffers
Guest author Tindall's final installment of a three-part series about buffers.
A Leaky Situation
John Hinshaw looks into a carrier-gas leak and its effects on the chromatographic baseline.
A Volatile Ion-Pairing Chromatography Reagent for an LC–MS Mobile Phase
This article presents a volatile ion-pairing reagent that enables good retention of highly polar anionic species using reversed-phase LC–MS.
Polymicro Technologies, LLC
Corporate profile for Polymicro Technologies, LLC. For more information see the company's web site at www.polymicro.com.
Isco, Inc.
Corporate profile for Isco, Inc. For more information see the company's web site at www.isco.com.
