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This article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.

A fast and easy-to-use method for the identifcation and determination of active anionic ingredients in toothpaste is presented using ion chromatography in combination with electrospray mass spectrometry. In this application, positive identification of glycerol, sorbitol, chloride, fluoride, sulphate, monofluorophosphate and polyphospates, in addition to citrate and saccharin, is achieved in one chromatographic run with a total analysis time of 22 min.

In the second instalment of this newly introduced column, Michael Balogh looks at resolution and mass accuracy as important considerations for determining the suitability of a mass spectrometer for an intended purpose.

This month's "Milestones in Chromatography" discusses the activities of F.F. Runge, a 19th century scientist whose investigations could be considered a precursor of chromatography.

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Valco Instruments Co., Inc. For more information, visit the company's website at www.valco.com.

Polymicro Technologies, LLC. For more information, visit the company's website at www.polymicro.com.

Valco Instruments Co., Inc. For more information, visit the company's website at www.valco.com.

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Vanessa R. Kinton, Gerstel, Inc., Kevin Goodner, USDA, Citrus and Subtropical Products Laboratory

In the first of this new column, Michael Balogh takes a look at source design and the strengths of multimode ionization, such as its ability to switch at high speeds between electrospray and atmospheric-pressure chemical ionization.

This article establishes the estimation of the uncertainty associated with the chromatographic determination of biogenic amines. The authors identify and estimate each source of uncertainty to establish the accuracy of results and to obtain a better understanding of the method. Thus, measurement uncertainty was split into two sections: uncertainty related to the working conditions, which considers the equipment used, and inherent uncertainty, which includes the chemical stages indicated in the procedure as well as calibration sources, taking into account the existence of the matrix effect. Recovery studies also were made to quantify the contribution of bias to the overall uncertainty. This parameter was calculated for the determination of biogenic amines in different types of samples.

This article describes the basis of OPLC and its instrumentation, and provides brief details of recent applications for which this technique is suited.

The authors used HPLC and CE to monitor changes in combinatorial genetics mediated secondary metabolite generation.

The authors describe a system for automated analytical temperature-rising elution fractionation that uses the built-in differential refractometer of a commercial gel-permeation chromatography instrument and a stop-flow method for sample crystallization.

The guest authors describe an in-tube SPME system coupled with capillary GC for the trace analysis of organic contaminants in water.

Leslie Ettre discusses four major application fields in which GC changed the way chemists carry out analyses.

John Dolan discusses system-related causes of peak broadening in isocratic reversed-phase LC.

Guest author Steve Scheuring suggests ways to choose and use gases in laboratories.