Selection of Optical Fiber for Chromatographic Detectors and Remote Sensing Applications
June 1st 2011Optical fibers are routinely used in liquid chromatographic detectors as a means of simplifying optical designs. Selection of the appropriate fiber is an important factor in achieving optimal system performance.
Reducing Cycle Time for Analysis of 1,4-Dioxane Using an Automated Purge and Trap Sample Prep System
June 1st 2011With advances in instrumentation and without regulatory method constraints, 1,4-dioxane can be detected at the part-per-billion (ppb) level, despite its poor purge efficiency. This application will manipulate purge and trap, as well as GC–MS parameters, to create a more efficient method to reduce cycle times. This study will utilize a Teledyne Tekmar Atomx Automated Sample Prep System in conjunction with an Agilent 7890/5975 GC–MS. A linear calibration and method detection limits (MDLs) for 1,4-dioxane will be established using this method.
Fast and Accurate LC–MS Analysis of Vitamin D Metabolites Using Ascentis® Express F5 HPLC Columns
June 1st 2011Vitamin D deficiency has become a topic of interest in recent publications (1–3). Vitamin D is present in two forms, Vitamin D3 and Vitamin D2. D3 is produced after ultraviolet light-stimulated conversion of 7-dehydrocholesterol in the skin (3).
Bioanalysis: LC-MS-MS, Sample Prep, and Dried Blood Spot Analysis
May 16th 2011Bioanalysis uses a variety of separation techniques to analyze samples ranging from plasma and urine to dried blood spots. Participants in this Technology Forum are Ling Bei, Patrik Appelblad, and Dave Lentz of EMD Millipore; Nadine Boudreau of PharmaNet Canada; Diab Elmashni, Jeff Zonderman, and Simon Szwandt of Thermo Fisher Scientific; and Debadeep Bhattacharya of Waters Corporation.