Collaboration yields E. coli discovery
The collaboration between the UK?s Health Protection Agency (HPA) and Thermo Fisher Scientific has led to a significant development in mapping the proteome of the organism responsible for the recent E. coli outbreak in Europe.
The collaboration between the UK’s Health Protection Agency (HPA) and Thermo Fisher Scientific has led to a significant development in mapping the proteome of the organism responsible for the recent E. coli outbreak in Europe. HPA researchers, using LTQ Orbitrap mass spectrometry technology, have identified the protein toxins expressed by the deadly strain that resulted in 37 deaths and made nearly 3400 people ill.
“The significance of this study is that scientists were able to develop techniques to study microorganisms and determine how the genetic code is being translated into the protein building blocks that determine traits such as toxicity,” said Dr Ian Jardine, vice president, global research and development, Thermo Fisher Scientific. “Our leading Orbitrap mass spectrometry system is providing researchers with the ability to understand what makes this E. coli strain so devastating, and may lead to an improved understanding of how to treat patients.”
Set up in 2003, the agency protects the public from the threats of infectious diseases and environmental hazards. The collaboration with Thermo Fisher studies the use of mass spectrometry to better understand the role of microorganisms in causing illness and disease in humans.
For more information on the technology, visit www.thermofisher.com
This story originally appeared in The Column. Click here to view that issue.
Determining Enhanced Sensitivity to Odors due to Anxiety-Associated Chemosignals with GC
May 8th 2025Based on their hypothesis that smelling anxiety chemosignals can, like visual anxiety induction, lead to an increase in odor sensitivity, a joint study between the University of Erlangen-Nuremberg (Erlangen, Germany) and the Fraunhofer Institute for Process Engineering and Packaging (Freising, Germany) combined behavioral experiments, odor profile analysis by a trained panel, and instrumental analysis of odorants (gas chromatography-olfactometry) and volatiles (gas chromatography-mass spectrometry).
Investigating 3D-Printable Stationary Phases in Liquid Chromatography
May 7th 20253D printing technology has potential in chromatography, but a major challenge is developing materials with both high porosity and robust mechanical properties. Recently, scientists compared the separation performances of eight different 3D printable stationary phases.
Detecting Hyper-Fast Chromatographic Peaks Using Ion Mobility Spectrometry
May 6th 2025Ion mobility spectrometers can detect trace compounds quickly, though they can face various issues with detecting certain peaks. University of Hannover scientists created a new system for resolving hyper-fast gas chromatography (GC) peaks.
