Rapid UHPLC Method Development for Omeprazole Analysis in a Quality-by-Design Framework and Transfer to HPLC Using Chromatographic Modeling
Quality-by-design principles are applied to build in a more scientific and risk-based multifactorial strategy in the development of a UHPLC method for analyzing a drug and its related impurities.
The Role of Selectivity in Extractions: A Case Study
The selective removal of a fat substitute in food products is discussed to demonstrate options for obtaining selectivity during extraction.
Troubleshooting Real GC Problems
Key considerations for setting up or troubleshooting a GC method.
The Future of Miniature Mass Spectrometers and a Path Forward: A Few Thoughts from an Academic Researcher
A discussion of the future role of miniature MS systems, the need for simplification in operation, the role of ambient ionization, and challenges in development and commercialization.
Significant Improvements in Pesticide Residue Analysis in Food Using the QuEChERS Method
The analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.
LC Method Scaling, Part I: Isocratic Separations
What kind of adjustments need to be made when scaling an isocratic method?
Peaks of Interest
The National Institute of Standards and Technology (NIST).
Vol 32 No 2 LCGC North America February 2014 Regular Issue PDF
Click the title above to open the LCGC North America February 2014 regular issue, Vol 32 No 2, in an interactive PDF format.
