The Benefits of Ion-Exchange Chromatography to Monitor Charge Heterogeneity in Monoclonal Antibodies
August 6th 2019The Column spoke to Richard Shannon from AstraZeneca about his work characterizing monoclonal antibodies (mAbs), why ion-exchange chromatography (IEC) is his technique of choice for analyzing mAbs, and offers his advice for anyone wanting to use the technique.
Meeting Review: Emerging Separation Technologies 2019
August 6th 2019Organized by The Chromatographic Society and the Separation Science Group of the Royal Society of Chemistry’s (RSC) analytical division, the Emerging Separation Technologies meeting was held on the 28 March 2019 at the RSC’s central London headquarters in Burlington House.
Tips & Tricks GPC/SEC: High Temperature GPC versus Ambient GPC
August 6th 2019Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard technique to determine the molar mass distribution of synthetic macromolecules. However, some kinds of polymers (for example, polyolefins) are often only soluble in special solvents and require high temperatures to be used during the analysis to keep the sample completely dissolved. Therefore, for the analysis of these polymers, dedicated high temperature GPC systems are used. This article will discuss the pros and cons of both high temperature GPC/SEC and ambient GPC/SEC.
Diagnosing Multiple Sclerosis Using Breath Biomarkers and GC–MS
August 6th 2019Researchers from the University of Huddersfield present new data and announce further studies which show great potential for the development of a for a noninvasive multiple sclerosis diagnostic tool which uses GC–MS.