The Application Notebook-09-02-2015

Click the title above to open the LCGC North America September 2015 Application Notebook, Vol 33 No s9, in an interactive PDF format.

In recent years, in the course of pharmaceuticals purified, as the need to chiral purification decreased since the improving of the asymmetric synthetic techniques, the desire to make medicine effective yet with a smaller number of doses and promised safety has raised

Diesel range organics or DRO is the cumulative analysis of extractable alkanes between the ranges C10 through C28 as measured on a flame ionization detector.

This project will evaluate the performance and versatility of the AutoMate-Q40 for the extraction of Imidazolinone herbicides.

Analysis of chromium species is made challenging due to the nature of the element and diverse sample matrices

Theanine is a neurologically active amino acid found in tea plants. L-Theanine is a dominant amino acid in green tea and is responsible for its unique pleasant taste as well as known relaxation effect.

Mycotoxin testing awareness has increased as countries involved in world trade of raw agriculture and processed consumer products rely on a safe global food supply

Due to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).

The ex vivo lability of some drug compounds and molecules in bio-analytical assays can add complexity and uncertainty to results and can pose significant challenges in drug development efforts.

Therapeutic antibodies are enjoying high growth rates in the pharmaceutical market. A majority of the top bestselling global drug brands are monoclonal antibodies (mAbs).

In his article, published in 2000, David V. McCalley found large increases in the efficiency for basic compounds at elevated temperature

Traditionally, simple analytical characteristics (for example, content of epoxy groups, chlorine, α-glycol groups, viscosity or softening point) are used to identify epoxy resins.

Scientists employ fused silica capillary tubing routinely in a wide range of analytical applications, encompassing GC, CE, capillary LC, and CEC. It has proven as an ideal substrate for interfacing in hyphenated techniques.

Complete separation of critical pain management drug analytes from hydrophilic matrix components and isobaric interferences was achieved using the new Raptor™ SPP Biphenyl LC column in less than 5 min

Avermectins are a series of 16-membered macrocyclic lactone derivatives that are used extensively in animal and crop protection

enable authentication of Si-Wu-Tang, a separate comprehensive 2D-LC analysis of each herb contained in Si-Wu-Tang was performed.

This application utilizes the original, non-buffered QuEChERS (acronym for quick, easy, cheap, effective, rugged, and safe) technique to quantify anabolic steroids in human whole blood

Polar neurotransmitters are difficult to retain using ODS columns. In this work we show two different methods to retain these polar analytes on the multi-mode Scherzo SS-C18 column. The versatility in retention characteristics with simple changes in mobile phase is highlighted.

The need for chiral detection in the development of pharmaceuticals is increasing due to regulatory changes and the demand for single-isomer pharmaceutical drugs

Click the title above to open the LCGC Europe September 2015 Application Notebook, Vol 27 No s9, in an interactive PDF format.