Application Notes

Combining a Phenomenex Gemini C18 LC column High Resolution, high accuracy mass spectrometry was used to resolve interferences observed during analysis of PFAS in plasma and serum.

This white paper explores L/dp ratio for pharmacopeia allowable adjustments. It considers efficiency, explaining why L/dp ratio can be used as a proxy for efficiency, and illustrates the allowable adjustments through reviewing at a selection of different monographs.

Comparison of blood collected using volumetric absorptive microsampling (VAMS) and serum for LC-MS/MS for analysis of a comprehensive PFAS panel

This white paper provides an in depth consideration of the new European Pharmacopeia monograph for the analysis of chlorhexidine and it’s related impurities. The white paper considers both column batch variation and system dwell volume.

A simplified SPE procedure using UCT’s HL DVB polymeric sorbent for the analysis of 64 Pharmaceuticals and Personal Care Products (PPCPs) in water according to EPA Method 16

Tire wear particles left on roads can cause marine and air pollution. Py-GC-MS identifies and quantifies microplastics present in air, sand, soil, and other materials.

Collection of most relevant automated sample preparation workflows for the TriPlus RSH SMART autosampler, including schematics, configurations, and links to additional resources, covering environmental and food safety applications.

This technical overview compares the characterization of NISTmAb using the ProteoAnalyzer with published NIST data obtained via traditional single capillary CE-SDS technology. The results show strong correlation with the reference data, confirming that the ProteoAnalyzer is a reliable tool for analytical workflows.

Particularly in the pharmaceutical industry, drug purity isn’t just a goal – it’s essential for achieving safety, stability and efficacy. However, purification is easier said than done, especially with challenging molecules like DNA and RNA “oligonucleotides,” due in large part to their diversity and the range of impurities that can be generated during production. Enter DAVISIL® chromatographic silica, with a wide range of pore diameters and particle sizes to meet your specific application, performance and sustainability requirements. Before you choose the chromatography resin for your next purification application, take a look at these 5 considerations.

Separation of free fatty acids from triglycerides can be inefficient and challenging, resulting in low yields. Whether using supercritical fluid chromatography or standard liquid chromatography, discover why DAVISIL® Chromatographic Silica has been referenced in third-party publications as the preferred separation medium because of its greater capacity. Learn more about Omega-3 Fatty Acids purification from Fish Oil in this technical data sheet.

Not all chromatography resins are created equal. Off-the-shelf chromatography resins might not always meet the rigorous purification requirements of biopharmaceutical manufacturing. Custom bonded silica from Grace can address a wide range of separation challenges, leading to real performance improvements. Discover more about the latest innovations in chromatography silica from Grace, including VYDAC® and DAVISIL®.

The optimized LC-MS/MS method covering 388 signaling lipids shows that the bioinert coated YMC Accura Triart C18 column combines high sensitivity with high resolution.

This application note describes the simultaneous extraction of aldosterone at low (< 25pg/mL) concentration and angiotensin I and II from plasma, with the potential to improve throughput and reduce time and costs in PRA determination.

App Note: This application notes demonstrates an automated Supported Liquid Extraction workflow in the analysis of Zolmitriptan, a selective serotonin receptor agonist, in plasma.

Customer Interview with Antonio Checa, a senior researcher at the Wheelock’s lab at the Karolina Institute describing automating the sample prep workflow in the analysis of lipid mediators such as oxylipinds.

Blog series: a break down of SPE Fundamentals to guide you in choosing the right tool and technique in solving bioanalytical problems.

Webinar: learn how Supported Liquid Extraction (SLE) can be an effective sample cleanup technique for Bioanalysis. The simple and efficient 3-step procedure provides consistent and reproducible results for a wide range of bioanalytical applications.

Webinar: Review of the fundamentals of common sample prep techniques, such as protein precipitation, liquid-liquid and supported liquid extraction, and solid-phase extraction, breaking down their mechanisms of action and highlighting strategies for choosing the best technique to use in bioanalysis.

Read about compliant analysis for the determination of ethanol and methanol content in fuels.

Discover an optimized GC/MS method conditions allowing faster analysis and increased throughput.

Read about this fast method providing excellent resolution and highly repeatable separations contributing to improve data quality while increasing lab productivity.

Discover how the PerkinElmer GC 2400™ Platform provides high level of precision for VOC analysis in paint.

Discover fast, robust, and sensitive analysis of alcohol in food with a new GC user-experience.

Discover an easy method that can help meet the most stringent purity requirements.

In this article, the results of a DIMS air monitoring campaign in Auckland, New Zealand, are described. Real-time SIFT–MS measurements were obtained at three sites over a period of several weeks. At each site, SIFT–MS provided effective on-site analysis to sub-ppbV levels with better than 1-min time resolution.

This application note describes the determination of method detection limits (MDLs) for the newly regulated HON (Hazardous Organic NESHAP) compounds, which validate SIFT-MS as an effective solution for measuring these toxic VOCs and other environmental pollutants in ambient air, whether at the fence line or in a mobile setting.