Application Notes: GC-MS

• Modern software makes tracking and scheduling maintenance more efficient • Systems schedule maintenance based on instrument usage

Aroma compounds in scented wax candles as well as aroma and odor emissions were determined by GC/MS after direct thermal extraction and air sampling with sorbent tubes.

Data acquired using the Centri® automated multi-mode sampling and preconcentration system for GC–MS can be used to generate insights into the aroma profiles of foods.

Dual GC poster that includes gas management selection chart and GC column selection chart

Zebron gas management filters and click-on GC traps remove contaminants from mobile-phase gases, reduce column bleed, increase column life, protect GC detectors.

Zebron gas management filter selection chart by the GC instrument and the fitting size

Zebron gas management filter selection chart by the GC instrument and the fitting size

Dual GC poster that includes gas management selection chart and GC column selection chart

Zebron gas management filters and click-on GC traps remove contaminants from mobile-phase gases, reduce column bleed, increase column life, protect GC detectors.

Zebron click-on trap step-by-step installation instruction

Zebron gas filter step-by-step installation instruction

Zebron click-on trap step-by-step installation instruction

Zebron gas filter step-by-step installation instruction

This application note presents thermal extraction of phthalates in accordance with IEC Method 62321-8 using a 6150 Pyroprobe.

Solvent-reduced determination of 100 contaminants from low double-digit to low triple-digit pg/L in 100 mL surface water samples, meeting the requirements of the EU-WFD based on SBSE-TD-GC-MS/MS

Quantifies affinity, stoichiometry of biomolecular assemblies, helping understand the mechanism of interaction and develop therapeutics that target and modulate them.

Quantifies affinity, stoichiometry of biomolecular assemblies, helping understand the mechanism of interaction and develop therapeutics that target and modulate them.

Most recently formulated pesticides are smaller in molecular weight and designed to break down rapidly in the environment.

SPME-GC–MS with on-column injection can be successfully employed for flavour profiling of food samples. The on-column injector of the GC-2010 can be used for SPME without any modifications, only an external ring adapter was used to facilitate the injection. The data can be compared with sensorial data of food.

The composition and analysis of fragrance components in home and personal care (HPC) products is very complex and unquestionably time consuming.

The QuEChERS method for pesticide analysis was first introduced by USDA scientists in 2003. The EN method 15662:2007 is a European variation to the QuEChERS method. The method uses acetonitrile extraction, followed by the salting out of water from the sample using anhydrous magnesium sulphate (MgSO4, NaCl and buffering citrate salts to induce liquid–liquid partitioning.

Polybrominated diphenyl ethers (PBDEs) are bioaccumulativetoxic compounds that are used as flame retardants. They have high boiling points and low thermal stability which makes analysis by GC–MS challenging. Additional bromines increase the thermal instability. A method was developed to analyze for polybrominated biphenyls using a large volume injection, short analytical column, and high mass tuning algorithm on the Thermo Scientific DSQ II with detection by EI Single Ion Monitoring (SIM).

Rapid sample preparation using the CUSTODIONâ„¢ solid phase microextraction (SPME) syringe was applied to chemical warfare agents (CWAs), CWA simulants, by-products, and precursors. The samples were analyzed quickly and reliably with a sample-to-sample cycle time of less than 3 min using the GUARDIONâ„¢-7 portable capillary gas chromatograph toroidal ion trap mass spectrometer (GC–TMS).

Illegal drug use worldwide is at an all time high. Forensic laboratories are seeing increased sample loads creating an immediate need for fast and accurate analysis to positively identify confiscated materials in criminal investigations. This application highlights the value of gas chromatography with time-of-flight mass spectrometry (GC-TOFMS) for drug testing in forensic laboratories. A method was developed to successfully identify twenty drugs of abuse in 4.5 min. This GC-TOFMS method shows good chromatographic peak shape for even the most challenging drug analytes; even the peak shapes for amphetamine and methamphetamine were exceptional considering they were analyzed underivatized. The total ion chromatogram (TIC) for the twenty drug analytes is shown in Figure 1.

GC–MS method is presented for the quantitative determination and confirmation of melamine residues in milk products. The milk sample was cleaned up using Agilent's SampliQ SCX SPE cartridges before derivatization. The derived extracts were analysed by GC–MS with EI in synchronous SIM/scan mode on a Agilent J&W DB-5ms Ultra Inert column.

Polybrominated diphenyl ethers (PBDE) are persistent environmental contaminants that are being extensively studied by environmental researchers worldwide. Their potential for toxicological impacts on humans and wildlife has made them a focal point of regulatory agencies. Their widespread use as flame retardants in electronics, household furniture, and many other building materials has lead to a need for analysis of many different sample matrices, including very complex environmental samples.

The recent establishment of a 1 μg/g safety threshold for melamine in infant foods has led to an immediate need for more sensitive methods. Here we established GC–MS conditions for highly reproducible analyses and evaluated the effectiveness of both solvent-based and matrix-matched standards. Using this method, melamine and cyanuric acid were reliably detected at and below 1 μg/g in infant formula.

Melamine is an industrial chemical with a high nitrogen content that can cause kidney stones and lead to renal failure. In some instances, melamine has been added to baby formula and dairy products as a substitute for protein. This paper presents an efficient and definitive gas chromatography–mass spectrometry (GC–MS) method to identify melamine and related compounds based on the released US Food and Drug Administration (FDA) method.

Thermo

Purge and trap concentration (P&T) along with gas chromatographic analysis is a widely used method for the detection of volatile organic compounds (VOCs). This methodology was developed to achieve the high sensitivity necessary to determine VOCs in drinking water according to EPA Method 524.2. Research is now complete and the EPA currently proposes a revision to this method that may include a revised list of analytes including iodinated trihalomethanes, fuel oxygenates, and Contaminant Candidate List 3. This new method will be 524.3 and may include new parameter optimizations not previously permitted in 524.2 as well as the ability to use selective ion monitoring (SIM) analysis for troublesome compounds.