Trapping versus Fractionation
When discussing optimization and improvements to costly and time-consuming purification processes "trapping" columns can be an alternative to fractionation.
When discussing optimization and improvements to costly and time‑consuming purification processes “trapping” columns can be an alternative to fractionation. However, when trapping, the compound has to be recovered from the column and transferred into its powder form. This requires consideration of chemical properties, as well as technical realization. This article demonstrates this complexity based on examples of the flow schemes and the software workflow.
LCGC’s Year in Review: Highlights in Liquid Chromatography
December 20th 2024This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
