New Approaches to Protein Precipitation: Effective Phospholipid Removal Improves Results
In clinical and pharmaceutical testing, analkyses of drug compounds and their metabolites are often performed in complex biological matrices, such as plasma and whole blood.
In clinical and pharmaceutical testing, analkyses of drug compounds and their metabolites are often performed in complex biological matrices, such as plasma and whole blood. Endogenous components in plasma samples can negatively impact the accuracy and precision of analyses. New techniques to remove phospholipids from plasma samples have recently been developed to eliminate ion suppression effects that can occur from these compounds. Method development and additional steps are not required, making this a simple, fast and effective way of removing signal suppression effects.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
