Polymer Liquid Adsorption Chromatography
Copolymer analysis is challenging because at least two distributions can be present simultaneously: the molar mass distribution (MMD) and the chemical composition distribution (CCD).
While there are molar mass sensitive detectors for the determination of the MMD of homopolymers, the applicability of these detectors for copolymers suffers from potential co-elution in GPC/SEC and (in case of lightscattering) from the dependence of the dn/dc on composition. In addition, these detectors do not provide any insight into the CCD.
The CCD can be determined using several techniques including dual detection, which was discussed in the first chapter of this eBook. In this case, GPC/SEC separation based on the size (hydrodynamic volume) is applied and the CCD of, for example, block copolymers is determined using at least two different detectors.
Pittcon 2025: Xiao Su Discusses His Work in Electrochemical Separations
March 13th 2025In this video interview with Xiao Su, he dives deeper into the research that he and his team are conducting with redox-active polymers and the applicability of electrochemical approaches in separation science.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
Pittcon 2025: Kate Perrault Uptmor Talks About Multidimensional GC and Mentorship
March 13th 2025In our interview with Kate Perrault Uptmor, we asked her about the resources available for those interested in learning more about multidimensional chromatography, and current trends happening in separation science that are of particular note.
Analyzing Effects of Adverse Cardiovascular Events on Chronic Kidney Disease with HPLC
March 13th 2025Researchers investigated the potential association between plasma apolipoprotein M (APOM) levels and the risk of adverse cardiovascular outcomes in individuals with chronic kidney disease (CKD). Plasma sphingosine-1-phosphate (S1P) levels were measured by high performance liquid chromatography (HPLC).
