Polymer Liquid Adsorption Chromatography
Copolymer analysis is challenging because at least two distributions can be present simultaneously: the molar mass distribution (MMD) and the chemical composition distribution (CCD).
While there are molar mass sensitive detectors for the determination of the MMD of homopolymers, the applicability of these detectors for copolymers suffers from potential co-elution in GPC/SEC and (in case of lightscattering) from the dependence of the dn/dc on composition. In addition, these detectors do not provide any insight into the CCD.
The CCD can be determined using several techniques including dual detection, which was discussed in the first chapter of this eBook. In this case, GPC/SEC separation based on the size (hydrodynamic volume) is applied and the CCD of, for example, block copolymers is determined using at least two different detectors.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
2024 EAS Awardees Showcase Innovative Research in Analytical Science
November 20th 2024Scientists from the Massachusetts Institute of Technology, the University of Washington, and other leading institutions took the stage at the Eastern Analytical Symposium to accept awards and share insights into their research.
