Compositional Analysis by GPC/ SEC With Multiple Detection
GPC/SEC analysis reveals a multitude of molar mass information about unknown samples that are chemically simple or homogenous. However, results for copolymers may be compromised by the fact that fractions with different composition and different molar mass may co-elute.
There are different methods on how to characterize such samples:
• chemical composition analysis studied in GPC/ SEC mode by concentration detectors
• chemical heterogeneity analysis investigated by HPLC based on retention differences of samples with different composition
• comprehensive 2D analysis that allows samples to be separated by composition and molar mass simultaneously.
This article will discuss the chemical composition analysis with multiple detection, while the latter two will be discussed in the next two articles in this eBook.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
