Dried blood spot analysis
A collaboration has been agreed between AB SCIEX and Alturas Analytics to accelerate the adoption of dried blood spot analysis for drug discovery and development.
A collaboration has been agreed between AB SCIEX and Alturas Analytics to accelerate the adoption of dried blood spot analysis for drug discovery and development. This analysis is designed to help pharmaceutical companies by simplifying the collection, storage and shipment of samples for pre-clinical and clinical studies in the drug development process. Scientists at Alturas are using QTRAP 5500 technology from AB SCIEX and micro-flow chromatography technology from Eksigent to further develop novel workflows based on microflow LC–MS for dried blood spot analysis and validate them to ensure that they meet Alturas’ quality assurance requirements. The new workflows are designed to require smaller sample volumes and provide sensitivity and low coefficient of variations.
“Dried blood spot analysis is a technique that can be used to solve complex bioanalytical problems,” said Shane Needham, laboratory director, Alturas Analytics. “Recent gains in sensitivity in analytical instrumentation have opened up remarkable new possibilities for pharmaceutical companies to take advantage of dried blood spot analysis.” Needham says that through their LC–MS instrumentation “AB SCIEX and Eksigent have helped to change the way we look at this type of analysis.“
For more information on these companies visit www.absciex.com and www.alturasanalytics.com
This story originally appeared in The Column. Click here to view that issue.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
