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The author takes a look at the problem of usually broad peaks and covers some techniques that will help determine the reasons behind them.

Columnist Ron Majors discusses methods that can be used to isolate large amounts of proteins from crude biological samples.

Leslie Ettre looks at the life of industry giants Jim Water and his contributions to the development of HPLC.

The applications of mass spectroscopy to clinical chemistry are discussed with the help of this month's featured scientists.

Here the authors discuss an ion-pair, gradient HPLC method, developed for cycloserine-related substances using a polar, amide-embedded C18 column. Other polar-embedded and polar-edcapped columns are evaluated in equivalence studies.

ESA Biosciences (Chelmsford, Massachusetts) recently announced that R&D Magazine selected the Corona charged aerosol detector for its prestigious 2005 R&D 100 Award.

News All the news from July 2005 Opinion Desperate to purchase some new chromatographic instruments for his research group, Zosimus asks why there aren't any critical reviews out there that can help him with his choice. Market trends & analysis Regular contributor Glenn Cudiamat provides a market profile of ion chromatography. Isocratic separation of Biopolymers Frantisek Svec discusses a new method aimed at facilitating the analysis of biopolymers isocratically in miniaturized column formats. Country focus Italy is the focus this month with a number of research projects to report on including life on Mars. Q&A Uwe Lehmann from SLS Micro Technology answers our questions on miniaturized systems for chromatography.

Applied Biosystems, MDS Sciex, and Dionex Corporation form alliance

Thermo Electron Corporation has recently been presented with two Omega NorthFace ScoreBoard awards for excellence in customer service.

News All the news from June 2005 Opinion This month Zosimus takes another swipe at scientific publishing by asking the question "Does Peer Review Work?" Market trends & analysis Regular contributor Glenn Cudiamat examines the market for thin-layer chromatography. Country focus Scandinavia is the centre of attention for June. Biotech developments, society news and company acquisitions are all on the agenda. Q&A Michael McBrien, from ACD/Labs answers our questions on computer-assisted method-development technologies and how they can make life easier for the research scientist.

Agilent (Palo Alto, California) recently announced plans to open a new training center in Shanghai, China.

In this initial instalment, several MS technologies and strategies currently being applied to characterize drug candidates in early stage development are presented.

The authors outline the ways in which forced degradation is used to develop a stability-indicating method and examine some of the method development and validation parameters critical to its success.

Agilent (Palo Alto, California) recently announced plans to open a new training center in Shanghai, China.

Reversed-phase high performance liquid chromatography (HPLC) is one of the most utilized forms of chromatography (1). The C8 and C18 stationary phases are the most widely used for reversed-phase HPLC. However, analysts occasionally encounter difficult separations for which selectivity, ruggedness, or reproducibility are not obtained easily using traditional C8 and C18 phases. These separations might require the use of novel or selective phases that interact with analytes in a manner different than C8 or C18 phases (2). These types of stationary phases separate compounds based upon selective stationary phase interactions such as steric recognition charge transfer or ?–? interactions (3). One class of selective or novel phases that have been used for a variety of separations are fluorinated phases (4). These fluorinated phases have provided an alternative and complementary separation for many analytes performed on C8 or C18 columns. Fluorinated phases can provide different elution orders, leading to..

LECO Corporation. For more information, visit the company's website at www.leco.com.

Waters Corporation. For more information, visit the company's website at www.waters.com.

2004 Author-Subject Index

Phenomenex, Inc. For more information, visit the company's website at www.phenomenex.com.

Waters Corporation. For more information, visit the company's website at www.waters.com.

Wyatt Technology Corporation. For more information, visit the company's website at www.wyatt.com.