Strategies for The Purification of Synthetic Products in The Pharmaceutical Industry
December 1st 2005By taking advantage of the benefits provided by normal-phase mode, highly productive and cost-effective strategies for high-throughput purification of drug discovery products have been developed in the analytical laboratories at Lilly-Spain. The straightforward scaling-up of generic protocols from an analytical to a preparative scale has yielded successful results not only when working in HPLC but also when transferring conditions to other standard low and medium pressure chromatographic systems that are routinely used by synthetic chemists.
Micropipette Tip-Based Sample Preparation for Bioanalysis
December 1st 2005The micropipette tip containing solid phases is a relatively new sample preparation format that permits the handling of microlitre and submicrolitre amounts of liquid samples using the techniques of solid-phase extraction, dialysis and enzyme digestion. Phases are packed, embedded or coated on the walls of the pipette, permitting liquid samples to be moved and transferred without undue pressure drop or plugging. This column reviews the latest technologies in micropipette tip sample preparation used in the study of genomics, proteomics and metabolomics.
Desty award winner and Eksigent expansion
December 1st 2005Dr Perdita Barran from the University of Edinburgh has won the coveted Desty Memorial Award for Innovation in Separation Science. Her work involved the use of ion mobile mass spectrometry (IM–MS) to analyse proteins and peptides and involved custom-building an ion mobility mass spectrometer. The findings of the research could be useful in helping to develop new classes of antibiotics and drugs to treat diseases of the reproductive system.
Determination of Stilbenes in Blueberries
November 1st 2005There is growing evidence that blueberries have powerful disease-fighting properties. Here the authors explore the research being done in this area, describing the use of a magnetic seector GC-MS SIM method to determine the presence of phenolic antioxidants in blueberries.
Profiles in Practice: Advances in Science and Geopolitical Issues
November 1st 2005The Centers for Disease Control and Prevention (CDC) estimates that each year in the United States, 76 million people get sick, 325000 are hospitalized and 5000 die from food-related illnesses. Food-borne illness is a serious public health problem. -National Library for the Environment, Food Safety Issues in the 107th Congress, 2001, Donna U. Vogt.