PNNL Recognized for Technology Transfer for ESI Transmitter
February 8th 2012The Federal Laboratory Consortium is recognizing the U.S. Department of Energy?s Pacific Northwest National Laboratory (PNNL) (Richland, Washington) for bringing a laboratory-developed technology that improves research sample analysis to the marketplace.
Trace Metabolic Profiling and Pathway Analysis of Clomazone Using LC–MS-MS and High Resolution MS
February 1st 2012Detection, analysis, and characterization of low-abundant metabolites remain an unresolved problem in metabolic studies. In this study, we report a novel approach to address this challenge. The current methodology is derived from the predictive multiple reaction monitoring (pMRM) mode available on triple-quadrupole linear ion trap mass spectrometry (MS) systems. The pMRM mode offers the highest sensitivity among various acquisition modes for studying trace levels of metabolites of the herbicide clomazone in plants. Additionally, this method allows for the identification of positional isomers of metabolites.