Monday Afternoon Session Preview: Clinical Chemistry: Dried Blood Spot Analysis
June 5th 2013Monday afternoon?s six presentations will focus on dried blood spot analysis, including the development of enzyme assays based on tandem mass spectrometry for the detection of lysosomal storage disorders; analysis of hemoglobin peptides in tryptic digests of dried-blood spot extracts; in-paper dried blood spot enzyme assays to determine plasma enzyme activities; the determination of neonatal paraben exposure; the introduction of a ?detergent-assisted elution? to improve analyte elution efficiency in dried matrix spot bioanalytical assays by UHPLC?MS-MS; and a method to quantify peptides from insulin-like growth factor-1 and its synthetic analogues in dried blood spots by LC?MS-MS.
Tuesday Morning Session Preview: Ion Mobility: Separations
June 5th 2013The six presentations in this Tuesday morning session will examine various topics in ion mobility spectrometry, including an approach for ion manipulations, calibration standards, stereoisomer separation, petroleomics, and protein self assembly.
The 2013 Emerging Leader in Chromatography: Davy Guillarme
June 4th 2013LCGC's 2013 Emerging Leader in Chromatography award winner Davy Guillarme, a senior lecturer at the University of Geneva, University of Lausanne, in Geneva, Switzerland, recently spoke to us about how his career began and where his research is leading him now.
The LCGC Blog: Retention Shifts in HPLC
June 3rd 2013The nature of retention time changes in HPLC tends to fall into categories. Firstly, the retention time may "drift" over several injections or several analytical campaigns and secondly, the retention time may suddenly "jump to a different value between injections or between analytical campaigns (i.e. analyte retention times are very different to when that method was run last).
Malvern enters grinding & dispersing market
June 3rd 2013Malvern Instruments (Malvern, UK) has entered a three year co-marketing agreement with Netzsch Grinding and Dispersing (Selb, Germany). The two companies serve shared markets including food, ceramics, pharmaceuticals, nano-technology applications, and surface coatings through to metal and mineral mining.
The science of Aboriginal smoking ceremonies
June 3rd 2013Two researchers from the University of New England in Armidale, Australia, have investigated the traditional medicines used in Australian Aboriginal cultures using gas chromatography- mass spectrometry (GC-MS) and gas chromatography with flame ionization detection (GC-FID).1
Assay for ppm Levels of Azide in Drug Substances
June 1st 2013The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of this impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC. The method is shown to be suitable for the intended purpose on three example test materials. Potential issues for wider applications are discussed.