Special Issues-10-15-2010

Analytical methods are developed at various stages of the drug develoment process for samples of varying complexity.

Pharmaceutical research and development (R&D) organizations were early adopters who recognized the many benefits of UltraPerformance LC? (UPLC?) Technology including resolution, sensitivity, throughput, and productivity as compared to HPLC.

Despite recent advances in column technology and stationary phase chemistry, challenges still remain for routine method development and LC/MS applications.

Method validation is a demanding activity. It requires a large investment in personnel, materials, instruments, supervision, and, most of all, time.