LCGC North America-12-01-2017

What are the most useful chromatography books on your bookshelf? What are the most useful web-based resources (such as websites, downloadable documents, videos) about separation science? What are the most useful tools supporting your work (such as calculators and simulators)? In this installment, Dwight Stoll compiles input from the separation science community (both individuals and vendors) to guide you to the resources that people find most useful.

A number of approaches for peak shape measurement are available in modern chromatography software. We discuss the advantages and drawbacks of those approaches, and present a new concept, “total peak shape analysis.”

In the environmental analytical chemistry literature, the topic of matrix interferences and matrix effects has not been addressed in a fundamental way. Here, we examine which methods appear to have a tendency for matrix interference and suggest ways to reduce the problem.

To address the challenges of analyzing new illicit drugs, emerging techniques such as UHPSFC with MS and UV detection, and GC with VUV detection, may be needed, particularly for distinguishing positional isomers and diastereomers.

A common challenge in LLE is the formation of emulsions. Several approaches can address the problem. Or, one can try an alternative technique.

Several key applications of biolayer interferometry in pharmaceutical development have emerged recently. Here, we evaluate its use for easuring product titer from fermentation, and compare the strengths and weaknesses of the technique to those of HPLC.

Click the title above to open the LCGC North America December 2017 regular issue, Vol 35 No 12, in an interactive PDF format.