LCGC North America-04-01-2007

LC-MS-MS has become a widely used technique for the fast and sensitive quantitation of small molecules. In this article, this approach has been extended to high-throughput quantitative LC-MS-MS analysis under GLP applications for a drug candidate in development from preclinical animal studies through clinical development.

Today's laboratories are sophisticated, generate large amounts of data, and rely on electronic data collection and tracking via a laboratory information management system (LIMS).

Prompted by a recently reviewed manuscript and a question from a reader, John Dolan examines the variability of retention times observed in LC methods in this month's installment of "LC Troubleshooting."

In this month's "MS-The Practical Art," Michael Balogh takes a closer look at insight provided by Chuck McEwen regarding obstacles while using solvents.

Guest columnist Volker Schurig discusses the achievements of Emanuel Gil-Av in introducing enantioselectivity into chromatographic analysis.

This month's installment of "Column Watch" is the conclusion of a two-part series in which columnist Ron Majors examines trends in column and sample prep introductions at Pittcon 2007.

The Gold Editors' Choice Awards was presented to Waters Corporation (Waltham, Massachusetts) for the Synapt HD–MS system at Pittcon 2007 in Chicago, Illinois. Silver Awards were presented to Paraytec (York, United Kingdom) for the ActiPix and Thermo Fisher Scientific (San Jose, California) for the LTQ ETD system. Bronze Awards were presented to Bruker Optics (Billerica, Massachusetts) for the ALPHA FT-IR system and Horiba Jobin Yvon (Edison, New Jersey) for the Activa system.