Next-Gen Sorbent-Based Extractions with Metal-Organic Frameworks
A review of cutting-edge analytical extractions using metal-organic frameworks (MOFs), including a description of what MOFs are, their preparation, principles of use, advantages, and application areas.
Hydrophobic Interaction Chromatography (HIC) for the Characterization of Therapeutic Monoclonal Antibodies and Related Products, Part 1: Theoretical Aspects
A review of the current state of HIC, focusing on retention and separation mechanisms with the aim of developing more robust methods. Can HIC be considered as a non-denaturing and non-destructive technique with advantages for protein analysis?
Non-aqueous Ion-Exchange Chromatography Using High Acid-base Concentration: A Strategy for Purifying Non-crystalline Pharmaceutical Intermediates
Ion-exchange chromatography (IEX) is a frequently overlooked technique. This novel IEX method uses non-aqueous mobile phases to purify a non-crystalline intermediate after a reductive amination with D-xylose. IEX delivers a step change in strength and purity of the intermediate allowing successful downstream processing.
Surfing on Mobile Phase, Part 2: Impact of Mobile Phase Composition Waves on Retention in LC
How do the characteristics of the mobile phase waves and retention properties of an analyte of interest impact retention precision?
Let’s Get Small - Powerful Gas Chromatography in Small Packages
With full laboratory capability now available in smaller systems, the possibilities for rethinking our use of gas chromatography (GC) both inside and outside the laboratory are (almost) endless.
