February 2023

Pittcon is back in-person from 18–22 March 2023, in Philadelphia, Pennsylvania, USA.

In this first TRLC instalment, our recent developments, new possibilities, and current limitations of the use of 1D TRLC are discussed, while the column performance is described with respect to the fundamentals of HPLC.

In this instalment, we review the basic thermodynamics underlying separation in GC, and we see how this impacts selectivity and retention.

In this latest instalment of our series on recurring challenges in liquid chromatography (LC), we turn our attention to peak widths that are wider than expected. Estimating the expected peak widths can help determine when a column and LC system are not working quite right, and to decide when troubleshooting should be initiated.

This article reviews a range of techniques available for separative analysis of mRNA therapeutics, their associated impurities, and delivery vehicles.