February 2021

A review of the operating principles of modern liquid chromatography (LC) pumps based on low- and high-pressure mixing designs, and a look at how these pumps produce mobile phase streams with small short-term variations in mobile phase composition, with a focus on the effect of these mobile-phase composition “waves” on detector baselines.

Mixed-mode chromatography columns are on the rise. This article reviews recent fundamental research, stationary phase development and design, and areas of application.

Mass spectrometry (MS) is the most powerful detector available for gas chromatography (GC). This article reviews the fundamentals of MS/MS and how they relate to MS as a detector for GC, then examines scenarios where use of GC–MS/MS can solve complex problems.

An overview of the analytical approaches proposed, from sample preparation to the final chromatographic determination, for the reliable risk assessment of mineral oil hydrocarbon (MOH) contaminants in food. The analysis of these contaminants in food is a challenging task and requires a comprehensive approach to tackle the cumbersome issues related to their determination.

In September, the World Health Organization (WHO) issued a new guidance document on Good Chromatography Practices. What guidance does it contain and is it useful? Has the document failed its system suitability test (SST) acceptance criteria?