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Nemal Gobalasingham

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Articles

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Characterizing Protein-Nucleic Acid Conjugates with Light Scattering

Nemal Gobalasingham;Sophia Kenrick
November 12th 2018

This article presents two case studies regarding the characterization of protein-DNA complexes using two complementary multi-angle light scattering (MALS) techniques, namely size-exclusion chromatography (SEC–MALS) to determine absolute molar mass of each component, and composition-gradient MALS (CG–MALS) to quantify stoichiometry and affinity at binding sites in solution.

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