John Chasse

A technique to measure total phenolic content (TPC) in vegetable oils through analysis of images captured by a cellphone may prove to be easier to utilize than the traditional methods of ultraviolet/visible (UV-vis) spectrophotometry, high-performance liquid chromatography (HPLC), and gas chromatography (GC).

The effects of simulated digestion on the formation of α-dicarbonyl compounds (α-DCs) in chocolates were assessed in a recent study with high-performance liquid chromatography (HPLC).

A recent paper introduced a compressed fluid-based separation process that combines carbon dioxide and ethanol to isolate portisins previously hemi-synthesized from blueberry surplus anthocyanins. The performance of the two-step separation process was compared favorably to centrifugal partitional chromatography (CPC) and conventional reversed-phase liquid chromatography (RPLC) findings that were reported in terms of portisins content in the extract, process throughput, process efficiency, and total solvent used.

Researchers investigated the use of electric field in dried blood spot (DBS) sample preparation for the detection of steroids in newborns using liquid chromatography-tandem mass spectrometry (LC-MS/MS) using both regular electroporation cuvettes and a custom vial setup.

A recent paper discusses advances in hydrophilic interaction chromatography (HILIC) in the analysis of therapeutic oligonucleotides and their impurities.

In this article, the editors of LCGC highlight some newly released laboratory products from instrument manufacturers around the world.

Exum Industries, producers of the first laser ablation laser ionization time of flight mass spectrometer (LALI-TOF-MS), announced a partnership with Edge Scientific to better promote and distribute their products.

The global portable spectrometer market is expected to reach over $4 million by 2030, according to a new market research report.

Researchers propose a suite of batch effect removal neural networks in large liquid chromatography-mass spectrometry experiments to maximize sample classification performance between conditions.

LCGC spoke with key opinion leaders on the cutting edge of analytical science (both from academia and the private sector) to gauge the evolution of a variety of techniques and the opportunities this evolution will present.

Researchers have utilized ultra-high performance liquid chromatography-tandem mass spectrometry (UH PLC-MS/MS) to monitor 5-Fluorouracil, a medication used to treat various cancers, in dried blood spots. This process offers a simpler, more efficient method than those in place involving the monitoring of plasma.

A report estimates that the market for chromatography software will grow at an 8.92% CAGR between 2023 and 2033.

A report estimates that the market for high performance liquid chromatography equipment will grow at a 4.61% CAGR between 2023 and 2033.

Richard Bade of the Queensland Alliance for Environmental Health Sciences (QAEHS) within The University of Queensland (Australia) and colleagues have recently published a paper outlining the development and application of a new workflow utilizing the open-source platform InSpectra, aiming to complement targeted analysis and identify geographical spatial trends in wastewater samples across multiple countries. Bade spoke to LCGC International about their research paper and the work that inspired it.

In this interview to commemorate Earth Day, Ana Torres-Agullo and Silvia Lacorte share the results of using Pyr-GC-Orbitrap-MS to simultaneously determine the presence of 10 polymers in the air.

This two-part session focused on metabolomics and lipidomics, to better understand the science of cellular biology.

Scientists at the Analytica conference in Munich, Germany, spoke about clinical mass spectrometry and its use in metabolomics and lipidomics.

In this interview, Kevin Schug discusses his work using untargeted analysis and differentiation of psilocybin mushroom strains.

At the 2024 Pittcon Conference, Elizabeth Humston-Fulmer of LECO Corporation presented an improved workflow which uses two-dimensional gas chromatography (GCxGC) with dual time of flight (TOF) MS/FID detection. Shortly after Pittcon, Humston-Fulmer discussed this analytical method with us.

At the conference in San Diego, experts presented on a variety of trends in mass spectrometry for pharmaceuticals.

This year's awards were presented to Martina Catani and Wolfgang Lindner.

These lectures focused on method development and applications of mass spectrometry for bioanalytical, natural product, and agricultural studies.

The Dal Nogare Award is presented yearly to an outstanding scientist in the field of chromatography.

The award recognizes outstanding contributions to the field of separation science by a young chemist or chemical engineer from academia, industry, or national laboratories.

The AES Mid-Career Award recognizes exceptional contributions to the field of electrophoresis, microfluidics, and related areas by an individual who is currently in the middle of their career. This year’s recipient, Robbyn K. Anand, Suresh Faculty Fellow and Carlyle G. Caldwell Endowed Chair in Chemistry at Iowa State University, has, along with her group, developed methods for circulating tumor cell analysis, electrokinetic enrichment and separation of chemical species within water-in-oil droplets, and more sensitive bioanalysis at arrays of wireless bipolar electrodes (1).

Five prior winners of our annual Emerging Leader Award give their perspectives on how to thrive and find success in the separation science field.

At Pittcon 2023, LCGC spoke with Peter Schoenmakers of the University of Amsterdam, who is the winner of our 2023 Lifetime Achievement in Chromatography Award. This segment previews one of three Pittcon interviews that were conducted at the conference.

At Pittcon 2023, LCGC spoke with Emanuela Gionfriddo of the University of Toledo, who is the winner of our 2023 Emerging Leader in Chromatography Award. This segment previews one of three Pittcon interviews that were conducted at the conference.

At Pittcon 2023, LCGC spoke with Jim Grinias of Rowan University. This segment previews one of three Pittcon interviews that were conducted at the conference.

Top-down mass spectrometry (TD-MS) of peptides and proteins results in product ions that can be correlated to the polypeptide sequence. Joseph Loo and colleagues at the University of California-Los Angeles (UCLA) have developed ClipMS, an algorithm assigning both terminal and internal fragments generated by TD-MS fragmentation, which can be used to locate various modifications on the protein sequence.