Application Notes: Sample Prep

This study shows the advantages of automated immersive sorptive extraction for the GC–MS analysis of a wide range of aroma compounds in vodka.

See the advantage in optimizing your solvent evaporation for maximum accuracy and precision to comply with U.S. EPA Method 625.1

Aroma compounds in scented wax candles as well as aroma and odor emissions were determined by GC/MS after direct thermal extraction and air sampling with sorbent tubes.

Implementing a peptide screening SPE plate determines the appropriate choice for a wide range of chemically diverse peptides.

The optimized dual solid phase extraction (SPE) method was developed to significantly reduce the surfactant background from formulated drug products.

A HILIC solid phase extraction (SPE) and LC method that results in sensitive, effective, and a time savings for the clean-up of N-Glycans.

A fast analytical method including both sample preparation and LC–ƒMS/MS analysis of ibuprofen in human plasma.

Implementing a peptide screening SPE plate determines the appropriate choice for a wide range of chemically diverse peptides.

The optimized dual solid phase extraction (SPE) method was developed to significantly reduce the surfactant background from formulated drug products.

A HILIC solid phase extraction (SPE) and LC method that results in sensitive, effective, and a time savings for the clean-up of N-Glycans.

The development of a selective and rugged LC–MS/MS method for the quantitation of Amlodipine enantiomers in human plasma.

GenX, along with 24 other PFASs, are analyzed simultaneously to achieve sub-ppt reporting limits.

A reliable and efficient method was developed to determine the concentration sterols in olive oil by GC-FID.

The development of a selective and rugged LC–MS/MS method for the quantitation of Amlodipine enantiomers in human plasma.

SPE is used in combination with LC–MS/MS to analyze a panel of opiates from a urine sample.

Mycotoxin in grain are extracted using SPE to removes interferences followed by a rapid LC–MS/MS method.

Mycotoxin in grain are extracted using SPE to removes interferences followed by a rapid LC–MS/MS method.

GenX, along with 24 other PFASs, are analyzed simultaneously to achieve sub-ppt reporting limits.

A fast analytical method including both sample preparation and LC–ƒMS/MS analysis of ibuprofen in human plasma.

SPE is used in combination with LC–MS/MS to analyze a panel of opiates from a urine sample.

Optimize the LC–MS/MS workflow by using a SPE solution that provides in-well urine hydrolysis to save time.

Optimize the LC–MS/MS workflow by using a SPE solution that provides in-well urine hydrolysis to save time.

A reliable and efficient method was developed to determine the concentration sterols in olive oil by GC-FID.

Solvent-reduced determination of 100 contaminants from low double-digit to low triple-digit pg/L in 100 mL surface water samples, meeting the requirements of the EU-WFD based on SBSE-TD-GC-MS/MS

Eliminating laborious sample preparation, field-flow fractionation greatly facilitates the absolute characterization of lignosulfonates by multi-angle light scattering.

Plastics play a role in just about every market sector and research area including agriculture, food, packaging, pharmaceuticals, medical implants, and personal care products, making the potential leaching of additives like antioxidants or slip additives a major concern. In this article learn how the EDGE is able to extract additives from plastics in a fraction of the time of traditional techniques.

Analytically, OPPs can pose some challenges due to the wide diversity of physical structures and behavioral characteristics of individual analytes. This often results in individual extraction protocols being implemented for labs to meet regulatory compliances. With the FMS, Inc TurboTrace® ABN Multi Cartridge SPE system, and its ability to incorporate dual cartridge extractions, it is possible to pair analytes with dissimilar characteristics into a single, fully automated extraction process.

Analytically, OPPs can pose some challenges due to the wide diversity of physical structures and behavioral characteristics of individual analytes. This often results in individual extraction protocols being implemented for labs to meet regulatory compliances. With the FMS, Inc TurboTrace® ABN Multi Cartridge SPE system, and its ability to incorporate dual cartridge extractions, it is possible to pair analytes with dissimilar characteristics into a single, fully automated extraction process.

This application note describes the use of ISOLUTE SLE+ for extraction of estrone (E1) and estradiol (E2) from human serum. Analysis is performed by an HPLC-MS/MS method that gives limits of detection of 0.001 ng/mL without derivatization or fluoride adduct stabilization. ISOLUTE SLE+ products provides high analyte recoveries, no emulsion formation and significantly reduced sample preparation time compared to traditional liquid-liquid extraction.

11-nor-9-Carboxy-THC, also known as THCA or carboxy-THC, is the main secondary metabolite of THC (the active component of marijuana) formed in the human body [1]. THCA is excreted in urine in the form of glucuronide conjugates. THCA is not psychoactive but has a long half-life of up to several days or even weeks in very heavy users, thus determination of THCA in urine plays an important role in confirmation of marijuana consumption. The Substance Abuse and Mental Health Services Administration (SAMHSA) has set the THCA cutoff concentration of confirmatory testing at 15 ng/mL. Typical sample preparation methods for THCA in urine include liquid-liquid extraction (LLE) and solid phase extraction (SPE). This application utilizes a novel sample preparation technique, QuEChERS to effectively quantitate THCA levels in human urine.