Application Notes: Sample Prep

As synthetic oligonucleotide therapeutics traverse the drug-development path, there is an increasing need for TK and PK/PD studies in drug discovery and development.

Common frequently asked question for oligonucleotides. This includes questions about characterization to purification and from sample preparation to LC separation.

This technical note discusses a simple, yet quick and effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit.

Advance your oligonucleotide work, from sample preparation to analysis and purification

To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.

Clarity QSP provides an alternative trityl-on approach for separating truncated sequences and synthetic contaminants from the protected full-length sequence.

UCT offers a simple yet effective procedure to extract and monitor an extensive panel of opioids in blood and urine using solid-phase extraction (SPE) combined with UHPLCMS/MS.

This application note describes a simple and robust solid-phase extraction (SPE) procedure for amphetamines in blood, plasma/serum, urine, and tissue samples.

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.

Known carcinogen, acrylamide is formed during food production processes such as roasting. This study details the use of SIFT–MS to monitor for this VOC in real time.

This application note provides an optimised and validated fully automated sample preparation and LC–MS/MS analysis solution for seven target nitrosamines in two classes of drug substance.

A quick, easy, effective procedure to identify and quantitate Kratom analytes in blood and urine using Clean Screen® XCEL I SPE cartridges and a Selectra® C18 UHPLC column.

UCT’s polymeric Styre Screen® HLD sorbent analyzes a wide range of neutral drugs in oral fluid.

This application note describes a simple and robust solid-phase extraction (SPE) procedure for amphetamines in blood, plasma, serum, urine, and tissue samples.

This application note outlines a solid-phase extraction (SPE) and LC-MS/MS method for the analysis of 19 synthetic cannabinoids in urine

This application note describes a simple and robust solid-phase extraction (SPE) procedure for Chloroquine, Hydroxychloroquine, and Desethylchloroquine in urine.

This application note outlines a simple 3 step method for the extraction of Loperamide and its main metabolite, N-desmethyl Loperamide, from blood using UCT’s Clean Screen® XCEL I SPE columns.

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

Preventing aerosol contamination during pipetting helps you achieve reliable results. Here we address the main contamination mechanisms that need to be avoided.

Learn how automated solid-phase extraction (SPE) streamlines the analysis of semi-volatile organic compounds in wastewater, in compliance with U.S. EPA Method 625.1.

The use of high-capacity sorptive extraction with multi-step enrichment, for enhancing the analysis of VOCs, that contribute to the aroma & flavor of breakfast cereals

The performance of the Empore oil and grease solid-phase extraction disk under EPA Method 1664, while reducing the total volume of n-hexane by 40%, is demonstrated.  

This application note demonstrates the benefit of large volume preconcentration (LVP) for enhancing headspace analysis of trace-level VOCs that contribute to aroma & flavour in tomato paste.

This short application note demonstrates the effectiveness of the Microlute™ Protein Precipitation Plate for the removal of proteins.

Amino Acids analysis method according to European Pharmacopoeia to support development and production of biopharmaceuticals.

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.